GMNN and REPIN1

Number of citations of the paper that reports this interaction (PubMedID 16924111)
34

Data Source:
BioGRID (pull down)

		GMNN	REPIN1
Description		geminin DNA replication inhibitor	replication initiator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding	DNA Binding RNA Binding Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication	Regulation Of Transcription By RNA Polymerase II Regulation Of Fatty Acid Transport
Pathways		Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Circulating chemerin levels ( 25521368)
Interacting Genes		34 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SIX3 SMARCA4 ZNF250 ZNF439	5 interacting genes: GATA3 GMNN HDAC1 OGT UBC
Entrez ID		51053	29803
HPRD ID		06783	17966
Ensembl ID		ENSG00000112312	ENSG00000214022
Uniprot IDs		O75496	A0A090N8H1 Q9BWE0
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance E-box Binding Negative Regulation Of Locomotion TOR Signaling Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Motility Positive Regulation Of Binding Regulation Of Cellular Response To Growth Factor Stimulus Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Circadian Regulation Of Gene Expression Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Transcription Repressor Complex Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Animal Organ Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pro-T Cell Differentiation Parathyroid Hormone Secretion Krueppel-associated Box Domain Binding Protein O-linked Glycosylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Circadian Rhythm Protein Lysine Delactylase Activity Fungiform Papilla Formation Protein O-acetylglucosaminyltransferase Activity DNA Replication Preinitiation Complex Assembly N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity Nephric Duct Formation Regulation Of Thyroid Hormone Generation Positive Regulation Of Ureteric Bud Formation Ureter Maturation Positive Regulation Of Thyroid Hormone Generation Mast Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ureteric Bud Formation Interleukin-2 Receptor Binding Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Hemopoiesis
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