GMNN and HOXA11

Number of citations of the paper that reports this interaction (PMID 14973489)
53

Data Source:
HPRD (in vitro)

		GMNN	HOXA11
Gene Name		geminin, DNA replication inhibitor	homeobox A11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Transcription Factor Complex Protein-DNA Complex Protein Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding Repressing Transcription Factor Binding	Sequence-specific DNA Binding
	Biological Process	Mitotic Cell Cycle Protein Complex Assembly Negative Regulation Of DNA Replication Organ Morphogenesis Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated	Skeletal System Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Single Fertilization Mesodermal Cell Fate Specification Male Gonad Development Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Positive Regulation Of Cell Development Embryonic Limb Morphogenesis Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Transcription, DNA-templated Developmental Growth Uterus Development Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis
Pathways		DNA Replication Pre-Initiation M/G1 Transition Regulation of DNA replication Removal of licensing factors from origins CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex Cell Cycle, Mitotic Assembly of the pre-replicative complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ARNT AURKA CASP3 CCDC146 CDKN1A CDKN2A CDT1 CSNK2A1 HDAC1 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KAT7 MCM6 NCF1 PHC1 REPIN1 SCMH1 SIX3 SMARCA4 ZNF439	5 interactors: CREBBP GMNN MEIS1 PGBD3 YY1
Entrez ID		51053	3207
HPRD ID		06783	00846
Ensembl ID		ENSG00000112312	ENSG00000005073
Uniprot IDs		O75496	P31270
PDB IDs		1T6F 1UII 2LP0 2WVR 4BRY
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Macromolecule Biosynthetic Process Pattern Specification Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Embryonic Morphogenesis Anatomical Structure Morphogenesis Gene Expression Embryonic Organ Development Embryonic Organ Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Embryo Development Proximal/distal Pattern Formation Embryonic Skeletal System Morphogenesis Regulation Of Cell Cycle Multicellular Organismal Development Negative Regulation Of Cell Cycle Developmental Process Skeletal System Morphogenesis Organ Morphogenesis Regulation Of Cell Cycle Process Embryonic Limb Morphogenesis Embryonic Skeletal System Development Regulation Of Metabolic Process Limb Morphogenesis Skeletal System Development Metabolic Process Chromatin Modification Limb Development Organ Development System Development Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition Positive Regulation Of Transcription, DNA-templated	Anatomical Structure Morphogenesis Camera-type Eye Morphogenesis Transcription From RNA Polymerase II Promoter Eye Morphogenesis Organ Morphogenesis Response To Prostaglandin F Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Germ-line Stem Cell Maintenance Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Camera-type Eye Development Multicellular Organismal Development Eye Development Regulation Of Transcription From RNA Polymerase II Promoter Response To UV-C Regulation Of Gene Expression Anatomical Structure Development N-terminal Protein Amino Acid Acetylation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Megakaryocyte Development Developmental Process Transcription, DNA-templated Sensory Organ Development RNA Biosynthetic Process Megakaryocyte Differentiation Definitive Hemopoiesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Lens Morphogenesis In Camera-type Eye Regulation Of Cellular Response To Heat Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Negative Regulation Of DNA Replication Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress RNA Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Metabolic Process Cellular Response To UV Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?			ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hdac9 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Difference) ?			ascl2 c4b dab2ip dlk1 eya4 fabp3 fzd9 gas7 hdac9 hoxa5 hoxa9 hoxb13 ihh ipf1 isl1 mest mme pax6 ptgs2 rassf1 rbp1 scgb3a1 sept5 serpina5 sox1 sox17 tbx1 tff1 thy1
Tagcloud (Intersection) ?