SCMH1 and HK1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		SCMH1	HK1
Description		Scm polycomb group protein homolog 1	hexokinase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Membrane Raft
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity Peptidoglycan Binding Glucosamine Kinase Activity
	Biological Process	Regulation Of DNA-templated Transcription Heterochromatin Formation Negative Regulation Of DNA-templated Transcription	Intracellular Glucose Homeostasis Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response GDP-mannose Biosynthetic Process Hexose Metabolic Process Organophosphate Metabolic Process Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis GDP-mannose Biosynthetic Process From Mannose Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process
Pathways			Synthesis of GDP-mannose Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis
Drugs		Mercaptoethanol	alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine
Diseases			Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) General risk tolerance (MTAG) ( 30643258) Height ( 18391952 20881960 23563607 25282103) Hip circumference adjusted for BMI ( 34021172) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928)	Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Glycated hemoglobin levels ( 34059833 19096518 31213470 29483669 28898252 20858683) Glycemic traits (pregnancy) ( 23903356) HDL cholesterol levels ( 32203549) Hematocrit ( 19862010 32888494 27863252) Hemoglobin ( 32888494 19862010) Hemoglobin A1c levels ( 29844224 31217584) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Iris color (a* coordinate) ( 29109912) Iris color (b* coordinate) ( 29109912) Iron status biomarkers (ferritin levels) ( 33536631) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 20139978 27863252 32888494) Mean corpuscular volume ( 27863252 32888494 20139978) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Red blood cell count ( 27863252 32888494 20139978) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		23 interacting genes: EWSR1 FXR1 FXR2 GMNN HK1 HPCAL4 LYPLA2 LZTR1 MAGEA12 MAML3 MOB4 PCBD1 PHC1 PHC2 POLR2M RNF2 SFMBT1 SFMBT2 TMEM11 TOB1 TSC1 UBQLN1 UBQLN4	6 interacting genes: APP CFTR ENO2 SCMH1 VDAC1 VDAC2
Entrez ID		22955	3098
HPRD ID		11540	00809
Ensembl ID		ENSG00000010803	ENSG00000156515
Uniprot IDs		A0A8Q3SHN2 A0A8Q3SHR9 B3KMZ7 B4DWE6 Q96GD3	A0A994J753 A8K7J7 B3KXY9 P19367 P78542 Q59FD4
PDB IDs		2P0K	1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB
Enriched GO Terms of Interacting Partners?		PcG Protein Complex PRC1 Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sex Chromatin Chromatin Binding Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Metabolic Process Histone Binding Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Translation Regulator Activity Negative Regulation Of Biosynthetic Process Nucleus Positive Regulation Of MRNA Catabolic Process Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Gene Expression Positive Regulation Of MRNA Metabolic Process Aggresome Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Glucosamine Kinase Activity Memory T Cell Differentiation Negative Regulation Of Macroautophagy Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Maintenance Of ER Location Negative Regulation Of Catabolic Process Nucleoplasm Heterochromatin 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Perinuclear Region Of Cytoplasm Regulation Of Macroautophagy Regulation Of MRNA Stability Regulation Of RNA Stability	Membrane Raft Voltage-gated Monoatomic Anion Channel Activity Porin Activity Ceramide Binding Voltage-gated Monoatomic Ion Channel Activity Pore Complex Monoatomic Anion Transmembrane Transport Oxysterol Binding Monoatomic Anion Transport Mitochondrial Transmembrane Transport Phosphatidylcholine Binding Mitochondrial Transport Regulation Of Monoatomic Ion Transmembrane Transport Mitochondrial Nucleoid Cholesterol Binding Lipid Transport Cellular Response To CAMP Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transport Response To CAMP Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Anion Channel Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monoatomic Anion Transport Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Calcium Import Into The Mitochondrion Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process
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