EPN2 and RNF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EPN2	RNF8
Description		epsin 2	ring finger protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Cytoplasmic Vesicle	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Cadherin Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Sprouting Angiogenesis	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		42 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 RPS27A SMAD1 SNCA SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG	78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496
Entrez ID		22905	9025
HPRD ID		06271	11521
Ensembl ID		ENSG00000072134	ENSG00000112130
Uniprot IDs		O95208	O76064
PDB IDs			2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification WW Domain Binding Endosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Protein Sequestering Activity Protein Tag Activity Cytoplasmic Side Of Late Endosome Membrane Identical Protein Binding Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Lysosome Ubiquitin Protein Ligase Activity Regulation Of Signal Transduction Protein K6-linked Ubiquitination Protein Binding Intracellular Protein Localization Positive Regulation Of Cell Communication Receptor-mediated Endocytosis Cytoplasm Regulation Of Signaling Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Negative Regulation Of Signal Transduction Phosphoprotein Binding Clathrin Coat Of Coated Pit Mitochondrial Outer Membrane Positive Regulation Of Protein Ubiquitination Macromolecule Catabolic Process Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Establishment Of Protein Localization Positive Regulation Of Receptor Catabolic Process Regulation Of Cell Communication Postsynaptic Endocytic Zone Negative Regulation Of Translational Initiation Proteolysis Involved In Protein Catabolic Process Cytoplasmic Translation Lysosomal Membrane Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Protein Localization To Lysosome Positive Regulation Of Receptor Recycling Cytoplasmic Side Of Lysosomal Membrane Catabolic Process	Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding
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