EPN2 and TFAP2A

Number of citations of the paper that reports this interaction (PMID 10567358)
44

Data Source:
HPRD (in vivo)

		EPN2	TFAP2A
Gene Name		epsin 2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Clathrin Coat Of Endocytic Vesicle Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Intracellular Membrane-bounded Organelle
	Molecular Function	Lipid Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Corepressor Activity Chromatin Binding Transcription Coactivator Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	In Utero Embryonic Development Endocytosis Notch Signaling Pathway Embryonic Organ Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Outflow Tract Morphogenesis Keratinocyte Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Transcription From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Embryonic Body Morphogenesis Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Neural Crest Cell Development Anterior Neuropore Closure Trigeminal Nerve Development Oculomotor Nerve Formation Forebrain Neuron Development Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Embryonic Cranial Skeleton Morphogenesis Epidermis Morphogenesis Palate Development Lens Induction In Camera-type Eye Face Morphogenesis Bone Morphogenesis Eyelid Development In Camera-type Eye Cornea Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Basement Membrane Organization Metanephric Nephron Development Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APOE CLTC EPS15 ITSN1 LAPTM5 RNF11 TFAP2A TUBA1B UBC YWHAG	30 interactors: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CTNNB1 DEK EP300 EPN2 EPS15 GSTO2 HIP1 LDLRAP1 MAGI1 MKRN3 MYC NPM1 PPARG RB1 SP1 SRA1 SUMO4 SYT1 TP53 UBE2I WWP1 WWP2 YBX1
Entrez ID		22905	7020
HPRD ID		06271	00128
Ensembl ID		ENSG00000072134	ENSG00000137203
Uniprot IDs		I3L2H1 O95208	P05549
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Cell Death Establishment Of Localization In Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cellular Localization Intracellular Transport Membrane Organization Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Neuron Death Endocytosis Transport Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Process Regulation Of Neuron Death Regulation Of Cell Death Negative Regulation Of Transferase Activity Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Optic Cup Structural Organization Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Neuron Death Negative Regulation Of Cell Death Cellular Response To Organic Substance Post-Golgi Vesicle-mediated Transport Regulation Of Signaling Negative Regulation Of Signal Transduction Oculomotor Nerve Formation Positive Regulation Of Neurofibrillary Tangle Assembly Optic Vesicle Morphogenesis Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Negative Regulation Of Signaling G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Tooth Mineralization Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process	Cell Death Death Apoptotic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Viral Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Execution Phase Of Apoptosis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Glial Cell Apoptotic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Gene Expression Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Peptidase Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Cell Proliferation Regulation Of Cell Cycle Neuron Death Positive Regulation Of Gene Expression Regulation Of Cell Death Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Immune System Development Positive Regulation Of Proteolysis Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated
Tagcloud ?			blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs
Tagcloud (Difference) ?			blastocysts bts cdh3 cdx2 chir99021 continually cyp11a1 dome elf5 eomes ets2 feeders gcm1 gdf3 hand1 hsd17b1 mash2 nanog oct4 pd0325901 pparg smarca4 sox2 ssea tdk tead4 teratomas thap11 tscs
Tagcloud (Intersection) ?