EPN2 and PMEPA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EPN2	PMEPA1
Description		epsin 2	prostate transmembrane protein, androgen induced 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Cytoplasmic Vesicle	Golgi Membrane Endosome Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Cadherin Binding	Protein Binding WW Domain Binding R-SMAD Binding Protein Sequestering Activity
	Biological Process	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Sprouting Angiogenesis	Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of SMAD Protein Signal Transduction
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event) ( 33455090) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		42 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 RPS27A SMAD1 SNCA SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG	11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4
Entrez ID		22905	56937
HPRD ID		06271	09415
Ensembl ID		ENSG00000072134	ENSG00000124225
Uniprot IDs		O95208	Q5JY37 Q969W9
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification WW Domain Binding Endosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Protein Sequestering Activity Protein Tag Activity Cytoplasmic Side Of Late Endosome Membrane Identical Protein Binding Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Lysosome Ubiquitin Protein Ligase Activity Regulation Of Signal Transduction Protein K6-linked Ubiquitination Protein Binding Intracellular Protein Localization Positive Regulation Of Cell Communication Receptor-mediated Endocytosis Cytoplasm Regulation Of Signaling Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Negative Regulation Of Signal Transduction Phosphoprotein Binding Clathrin Coat Of Coated Pit Mitochondrial Outer Membrane Positive Regulation Of Protein Ubiquitination Macromolecule Catabolic Process Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Establishment Of Protein Localization Positive Regulation Of Receptor Catabolic Process Regulation Of Cell Communication Postsynaptic Endocytic Zone Negative Regulation Of Translational Initiation Proteolysis Involved In Protein Catabolic Process Cytoplasmic Translation Lysosomal Membrane Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Protein Localization To Lysosome Positive Regulation Of Receptor Recycling Cytoplasmic Side Of Lysosomal Membrane Catabolic Process	Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Ubiquitin Binding Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway ESCRT-0 Complex Regulation Of Protein Catabolic Process Establishment Of Protein Localization To Vacuole Dynactin Complex Protein Localization To Vacuole Autophagy Establishment Of Protein Localization To Organelle Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Exosomal Secretion Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of ERAD Pathway Regulation Of Exosomal Secretion Cytosol Regulation Of ERAD Pathway Ubiquitin-like Protein Ligase Binding Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Vacuolar Transport Protein Targeting To Lysosome Multivesicular Body Assembly Multivesicular Body Organization Regulation Of Macroautophagy Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Late Endosome To Vacuole Transport Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Protein Targeting To Vacuole Proteolysis Catabolic Process Protein Localization To Lysosome Proteolysis Involved In Protein Catabolic Process Formation Of Structure Involved In A Symbiotic Process Cytoplasm Receptor Internalization Channel Inhibitor Activity Regulation Of Cellular Response To Growth Factor Stimulus TRC Complex Positive Regulation Of Exocytosis Endosome Organization Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Regulation Of Autophagy
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