ANKRD6 and CSNK1E

Number of citations of the paper that reports this interaction (PMID 12183362)
51

Data Source:
HPRD (two hybrid, in vivo)

		ANKRD6	CSNK1E
Gene Name		ankyrin repeat domain 6	casein kinase 1, epsilon
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function		Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Positive Regulation Of JNK Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Repair Protein Phosphorylation Endocytosis Organelle Organization Signal Transduction Circadian Rhythm Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Cellular Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Organelle biogenesis and maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G2/M Transition Assembly of the primary cilium Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic WNT mediated activation of DVL Loss of proteins required for interphase microtubule organizationÂ from the centrosome TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Loss of Nlp from mitotic centrosomes XAV939 inhibits tankyrase, stabilizing AXIN Centrosome maturation Signaling by WNT in cancer Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		2 interactors: AXIN2 CSNK1E	40 interactors: AKAP9 ANKRD6 APC APP ARHGEF1 ARNTL AXIN1 AXIN2 BBS10 BID C2orf44 CADM4 CRY1 DVL1 DVL2 DVL3 FAM110A FAM110C FAM83D FBP1 GTF3C1 HES1 KAT7 MCC NCOA3 PER1 PER2 PER3 PNO1 PPP1CA PPP1R14A RAD54B RBX1 SDCCAG3 SOCS3 TAOK1 TAZ TNS2 ZMYND8 ZNF227
Entrez ID		22881	1454
HPRD ID		09798	02919
Ensembl ID		ENSG00000135299	ENSG00000213923
Uniprot IDs		B7Z3D2 Q9Y2G4	B0QY34 P49674 Q5U045
PDB IDs			4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Chondrocyte Development Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Mismatch Repair Regulation Of Wnt Signaling Pathway Maintenance Of DNA Repeat Elements Regulation Of Cell Morphogenesis Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Centromeric Sister Chromatid Cohesion Intramembranous Ossification Negative Regulation Of Catenin Import Into Nucleus Regulation Of Sister Chromatid Cohesion Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Heart Formation Specification Of Organ Identity Regulation Of Catenin Import Into Nucleus DNA Metabolic Process Dorsal/ventral Axis Specification Negative Regulation Of Signal Transduction MRNA Stabilization Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Signal Transduction Cellular Protein Localization Bone Mineralization Negative Regulation Of Osteoblast Differentiation Organ Formation Regulation Of MRNA Stability Positive Regulation Of Stem Cell Differentiation Regulation Of RNA Stability Regulation Of Epithelial To Mesenchymal Transition Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Regulation Of DNA Repair Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Import Into Nucleus Biomineral Tissue Development Negative Regulation Of Ossification Circadian Regulation Of Gene Expression Protein Localization Regulation Of Chromosome Segregation	Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Signal Transduction Wnt Signaling Pathway Signaling Regulation Of JNK Cascade Circadian Rhythm Cell Communication Canonical Wnt Signaling Pathway Regulation Of Stress-activated MAPK Cascade Planar Cell Polarity Pathway Involved In Neural Tube Closure Cochlea Development Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Differentiation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Kinase Activity Regulation Of Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stimulus Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelium Development Positive Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod
Tagcloud ?		analogous asymmetrically canonical consists coordinated core diego discovered drosophila ear emerging homolog inner neighboring organs pcp planar plane polarity polarization recurring rescue sensory shares suppress theme vertebrates wnt	accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a
Tagcloud (Difference) ?		analogous asymmetrically canonical consists coordinated core diego discovered drosophila ear emerging homolog inner neighboring organs pcp planar plane polarity polarization recurring rescue sensory shares suppress theme vertebrates wnt	accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a
Tagcloud (Intersection) ?