ANKRD6 and RIPK4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ANKRD6	RIPK4
Description		ankyrin repeat domain 6	receptor interacting serine/threonine kinase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function		Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Establishment Or Maintenance Of Cell Polarity Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 25827505) Coronary artery disease ( 29212778 33020668) Knee osteoarthritis ( 28916551) Metabolite levels (Pyroglutamine) ( 23934736) vWF and FVIII levels ( 21810271) Waist-hip ratio ( 28552196)	Femur bone mineral density x serum urate levels interaction ( 34046847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		3 interacting genes: AXIN2 CSNK1E RIPK4	38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP
Entrez ID		22881	54101
HPRD ID		09798	10419
Ensembl ID		ENSG00000135299	ENSG00000183421
Uniprot IDs		A0A384MEC3 A0AA34QVS0 B7Z3D2 Q9Y2G4	Q96T11 Q9H4D1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Canonical Wnt Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Mismatch Repair Regulation Of Wnt Signaling Pathway Intramembranous Ossification Regulation Of Centromeric Sister Chromatid Cohesion Regulation Of Chondrocyte Development Protein Serine Kinase Activity Maintenance Of DNA Repeat Elements Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Regulation Of Protein Catabolic Process Mitral Valve Morphogenesis Regulation Of Proteolysis Protein Serine/threonine Kinase Activity Osteoblast Proliferation Secondary Heart Field Specification Beta-catenin Destruction Complex Heart Field Specification Negative Regulation Of Osteoblast Proliferation Protein Kinase Activity Dorsal/ventral Axis Specification Positive Regulation Of Non-canonical Wnt Signaling Pathway I-SMAD Binding Specification Of Animal Organ Identity Positive Regulation Of Catabolic Process Regulation Of Sister Chromatid Cohesion Positive Regulation Of Amyloid-beta Formation Atrioventricular Valve Morphogenesis Circadian Behavior Kinase Activity Rhythmic Behavior Regulation Of Non-canonical Wnt Signaling Pathway Positive Regulation Of Amyloid Precursor Protein Catabolic Process DNA Metabolic Process Positive Regulation Of Amide Metabolic Process Cellular Response To Dexamethasone Stimulus Regulation Of Osteoblast Proliferation Aortic Valve Morphogenesis Positive Regulation Of Protein Metabolic Process	Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane
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