NLRP1 and CASP1

Number of citations of the paper that reports this interaction (PMID 17418785)
76

Data Source:
HPRD (in vivo)

		NLRP1	CASP1
Gene Name		NLR family, pyrin domain containing 1	caspase 1, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytosol NLRP1 Inflammasome Complex	Extracellular Region Cytoplasm Cytosol IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Domain Specific Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Muramyl Dipeptide Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Neuron Apoptotic Process	Response To Hypoxia Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Autophagy Response To Lipopolysaccharide Interleukin-1 Beta Production Response To ATP Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Mitochondrial Depolarization Membrane Hyperpolarization Pyroptosis Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Execution Phase Of Apoptosis Programmed Necrotic Cell Death Toxin Transport
Pathways		Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	Signaling by Interleukins The NLRP3 inflammasome Inflammasomes NOD1/2 Signaling Pathway The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Interleukin-1 processing The IPAF inflammasome Cytokine Signaling in Immune system Innate Immune System
Drugs			Minocycline 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD	42 interactors: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17 CARD8 CASP10 CASP14 CASP4 CASP8 CAST CDK11B EGFR FGF2 HTT IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARK2 PARP1 PLA2G4A PLA2G4B PSEN1 PSEN2 PYCARD RIPK2 TFAP2A TIRAP VAC14
Entrez ID		22861	834
HPRD ID		07364	00977
Ensembl ID		ENSG00000091592	ENSG00000137752
Uniprot IDs		E9PE50 Q9C000 Q9H5Z7	A8K249 A8K257 P29466
PDB IDs		1PN5 3KAT 4IFP	1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Apoptotic Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Response To External Stimulus Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Secretion Regulation Of Proteolysis Positive Regulation Of Signal Transduction Regulation Of Autophagy Response To Other Organism Regulation Of Interleukin-1 Beta Secretion Innate Immune Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Membrane Potential Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intracellular Signal Transduction Regulation Of Interleukin-1 Beta Production Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Neuron Apoptotic Process Pyroptosis Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Metabolic Process	Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Response To Stress Immune Response Signaling Regulation Of Signaling Cell Communication Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Proteolysis Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Negative Regulation Of Cell Death Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Localization Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Immune System Process Signal Transduction Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Protein Processing Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Positive Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Difference) ?		ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Intersection) ?