NLRP1 and APAF1

Number of citations of the paper that reports this interaction (PubMedID 11113115)
0

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vivo)

		NLRP1	APAF1
Description		NLR family pyrin domain containing 1	apoptotic peptidase activating factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex	Extracellular Region Nucleus Cytoplasm Cytosol Protein-containing Complex Secretory Granule Lumen Apoptosome Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Double-stranded DNA Binding Double-stranded RNA Binding Endopeptidase Activity Protein Binding ATP Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Signaling Adaptor Activity Pattern Recognition Receptor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Heat Shock Protein Binding Identical Protein Binding ADP Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Immune System Process Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Programmed Cell Death Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Neuron Apoptotic Process Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Pyroptotic Inflammatory Response Pyroptotic Cell Death NLRP1 Inflammasome Complex Assembly	Response To Hypoxia Kidney Development Neural Tube Closure Apoptotic Process Nervous System Development Brain Development Response To Nutrient Cardiac Muscle Cell Apoptotic Process Cell Differentiation Forebrain Development Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process System Development Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Transforming Growth Factor Beta Stimulus Response To G1 DNA Damage Checkpoint Signaling Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		The NLRP1 inflammasome	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			ATP
Diseases
GWAS		Migraine ( 27322543)	Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		10 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 MAPK14 NOD1 PYCARD	19 interacting genes: APIP AVEN BCL2L1 BCL2L10 CASP3 CASP4 CASP8 CASP9 CYCS FAS FEM1B HIP1 HSP90AA1 HSPA1A NLRP1 NUP107 PPP1CA TOP1 TRIAP1
Entrez ID		22861	317
HPRD ID		07364	03755
Ensembl ID		ENSG00000091592	ENSG00000120868
Uniprot IDs		Q9C000	O14727
PDB IDs		1PN5 3KAT 4IFP 4IM6 5Y3S 6K7V 6X6C 6XKK 7WGE 8ZGD	1C15 1CWW 1CY5 1Z6T 2P1H 2YGS 3J2T 3JBT 3YGS 4RHW 5JUY 5WVC 5WVE 8XQK
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Regulation Of Programmed Cell Death NLRP1 Inflammasome Complex Cellular Response To Stress Apoptotic Signaling Pathway Intracellular Signal Transduction Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Neuron Apoptotic Process Programmed Cell Death Involved In Cell Development Neuron Apoptotic Process Identical Protein Binding Protein Maturation Cysteine-type Peptidase Activity Signal Transduction Apoptosome Dendritic Cell Apoptotic Process AIM2 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Response To Virus Response To External Biotic Stimulus DNA Damage Response Pyroptotic Inflammatory Response Response To Stress Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Response To Mechanical Stimulus BH3 Domain Binding Positive Regulation Of Interleukin-1 Beta Production Response To Cytokine Positive Regulation Of Neuron Apoptotic Process Response To Peptide Osmosensory Signaling Pathway Positive Regulation Of Interleukin-1 Production NLRP3 Inflammasome Complex Cellular Response To Mechanical Stimulus Cytosol Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Response To Other Organism Cysteine-type Endopeptidase Activator Activity	Cell Death Programmed Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Response To Anesthetic Death-inducing Signaling Complex Positive Regulation Of Pyroptotic Inflammatory Response Response To Cobalt Ion Mitochondrion Leukocyte Apoptotic Process Neuron Apoptotic Process Positive Regulation Of Apoptotic Process Death Receptor Binding Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Activity Nucleus Positive Regulation Of Neuron Apoptotic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptosome Response To Radiation Execution Phase Of Apoptosis Positive Regulation Of Defense Response Negative Regulation Of Programmed Cell Death Response To Stress Glial Cell Apoptotic Process Cytosol Inflammatory Response CD95 Death-inducing Signaling Complex NLRP1 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Epithelial Cell Apoptotic Process Regulation Of Neuron Apoptotic Process Cysteine-type Peptidase Activity Negative Regulation Of Apoptotic Process Self Proteolysis Response To UV Fibroblast Apoptotic Process Intracellular Signal Transduction Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Maturation Cellular Response To Radiation Positive Regulation Of Inflammatory Response Response To Light Stimulus Interleukin-18-mediated Signaling Pathway
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