NLRP1 and PYCARD

Number of citations of the paper that reports this interaction (PubMedID 17418785)
0

Data Source:
HPRD (in vivo)

		NLRP1	PYCARD
Description		NLR family pyrin domain containing 1	PYD and CARD domain containing
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule IkappaB Kinase Complex Membrane Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Neuronal Cell Body Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex NLRP6 Inflammasome Complex
	Molecular Function	Nucleotide Binding Double-stranded DNA Binding Double-stranded RNA Binding Endopeptidase Activity Protein Binding ATP Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Signaling Adaptor Activity Pattern Recognition Receptor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity	Protease Binding Interleukin-6 Receptor Binding Protein Binding Tropomyosin Binding Myosin I Binding Enzyme Binding Pyrin Domain Binding Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Dimerization Activity BMP Receptor Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Immune System Process Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Programmed Cell Death Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Neuron Apoptotic Process Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Pyroptotic Inflammatory Response Pyroptotic Cell Death NLRP1 Inflammasome Complex Assembly	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Response To Bacterium Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Macropinocytosis NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of JNK Cascade Icosanoid Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Pyroptotic Inflammatory Response Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Inflammasome Complex Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		The NLRP1 inflammasome	CLEC7A/inflammasome pathway Neutrophil degranulation The NLRP3 inflammasome The AIM2 inflammasome Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases
GWAS		Migraine ( 27322543)	Post bronchodilator FEV1 ( 26634245)
Interacting Genes		10 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 MAPK14 NOD1 PYCARD	15 interacting genes: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 RUBCN SRF USP3 USP50 ZFYVE21
Entrez ID		22861	29108
HPRD ID		07364	06020
Ensembl ID		ENSG00000091592	ENSG00000103490
Uniprot IDs		Q9C000	Q9ULZ3
PDB IDs		1PN5 3KAT 4IFP 4IM6 5Y3S 6K7V 6X6C 6XKK 7WGE 8ZGD	1UCP 2KN6 3J63 5H8O 6K99 6KI0 6N1H 7E5B 7KEU
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Regulation Of Programmed Cell Death NLRP1 Inflammasome Complex Cellular Response To Stress Apoptotic Signaling Pathway Intracellular Signal Transduction Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Neuron Apoptotic Process Programmed Cell Death Involved In Cell Development Neuron Apoptotic Process Identical Protein Binding Protein Maturation Cysteine-type Peptidase Activity Signal Transduction Apoptosome Dendritic Cell Apoptotic Process AIM2 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Response To Virus Response To External Biotic Stimulus DNA Damage Response Pyroptotic Inflammatory Response Response To Stress Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Response To Mechanical Stimulus BH3 Domain Binding Positive Regulation Of Interleukin-1 Beta Production Response To Cytokine Positive Regulation Of Neuron Apoptotic Process Response To Peptide Osmosensory Signaling Pathway Positive Regulation Of Interleukin-1 Production NLRP3 Inflammasome Complex Cellular Response To Mechanical Stimulus Cytosol Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Response To Other Organism Cysteine-type Endopeptidase Activator Activity	Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Canonical Inflammasome Complex Pyroptotic Inflammatory Response Regulation Of Interleukin-18 Production Positive Regulation Of Inflammatory Response NLRP3 Inflammasome Complex Regulation Of Inflammatory Response Negative Regulation Of Interleukin-1 Production Regulation Of NLRP3 Inflammasome Complex Assembly Cysteine-type Endopeptidase Activator Activity Positive Regulation Of Interleukin-18 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Defense Response IPAF Inflammasome Complex Regulation Of Defense Response Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Inflammatory Response Positive Regulation Of Innate Immune Response Immune System Process Immune Response-activating Signaling Pathway NLRP1 Inflammasome Complex Negative Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Osmosensory Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Interleukin-18-mediated Signaling Pathway Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Defense Response Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response Negative Regulation Of Cytokine Production Positive Regulation Of Immune Response Cysteine-type Peptidase Activity Response To Other Organism
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