NLRP1 and PYCARD

Number of citations of the paper that reports this interaction (PMID 17418785)
76

Data Source:
HPRD (in vivo)

		NLRP1	PYCARD
Gene Name		NLR family, pyrin domain containing 1	PYD and CARD domain containing
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytosol NLRP1 Inflammasome Complex	Extracellular Region Nucleus Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol IkappaB Kinase Complex Neuronal Cell Body NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Domain Specific Binding	Protease Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pyrin Domain Binding Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Muramyl Dipeptide Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Neuron Apoptotic Process	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Rac GTPase Activity Interleukin-1 Beta Production Negative Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Macropinocytosis Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Chemokine Secretion Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of T Cell Migration Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Interleukin-10 Secretion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System	The NLRP3 inflammasome Inflammasomes The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD	11 interactors: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 SRF
Entrez ID		22861	29108
HPRD ID		07364	06020
Ensembl ID		ENSG00000091592	ENSG00000103490
Uniprot IDs		E9PE50 Q9C000 Q9H5Z7	Q9ULZ3
PDB IDs		1PN5 3KAT 4IFP	1UCP 2KN6
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Apoptotic Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Intracellular Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Response To External Stimulus Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Proteolysis Positive Regulation Of Interleukin-1 Secretion Regulation Of Proteolysis Positive Regulation Of Signal Transduction Regulation Of Autophagy Response To Other Organism Regulation Of Interleukin-1 Beta Secretion Innate Immune Response Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of Mitochondrial Membrane Potential Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intracellular Signal Transduction Regulation Of Interleukin-1 Beta Production Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Neuron Apoptotic Process Pyroptosis Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Metabolic Process	Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cytokine Secretion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cytokine Secretion Regulation Of Endopeptidase Activity Regulation Of Protein Secretion Immune System Process Regulation Of Peptidase Activity Innate Immune Response Positive Regulation Of Protein Secretion Intracellular Receptor Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Interleukin-1 Beta Production Positive Regulation Of Cellular Metabolic Process Protein Processing Regulation Of Cytokine Production Positive Regulation Of Hydrolase Activity Regulation Of Inflammatory Response Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Transport Regulation Of Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion Positive Regulation Of Protein Transport Immune Response Positive Regulation Of Cytokine Production Defense Response Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Localization Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity
Tagcloud ?		ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5	1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammasome inflammation initiate lean mhcii nlrp3 nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover
Tagcloud (Difference) ?		ancient archaea autoproteolysis autoproteolytic card8 deteriorated extend fam171 fiind gpcr gpcrs gps hfs hlt lrr nacht nucleoporin98 nup98 occluden origination polycystic precedes pyd searches subdomain unc5c upa zonula zu5	1beta adipocyte adipocytes adipose adiposity adjusting caspase contributions dialogue differentially escalate histocompatibility ifngamma inflammasome inflammation initiate lean mhcii nlrp3 nod obese obesity phenotypes secretion stromal subcutaneous svf transcriptome uncover
Tagcloud (Intersection) ?