NLRP1 and NOD1

Number of citations of the paper that reports this interaction (PubMedID 11113115)
0

Data Source:
HPRD (in vitro)

		NLRP1	NOD1
Description		NLR family pyrin domain containing 1	nucleotide binding oligomerization domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex	Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Phagocytic Vesicle
	Molecular Function	Nucleotide Binding Double-stranded DNA Binding Double-stranded RNA Binding Endopeptidase Activity Protein Binding ATP Binding Peptidase Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Signaling Adaptor Activity Pattern Recognition Receptor Activity Cysteine-type Endopeptidase Activator Activity Molecular Condensate Scaffold Activity	Nucleotide Binding Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Ubiquitin Binding Protein-containing Complex Binding CARD Domain Binding
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Immune System Process Proteolysis Apoptotic Process Inflammatory Response Signal Transduction Programmed Cell Death Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Homooligomerization Neuron Apoptotic Process Protein Maturation Defense Response To Virus Pyroptotic Inflammatory Response Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway Self Proteolysis Antiviral Innate Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Pyroptotic Inflammatory Response Pyroptotic Cell Death NLRP1 Inflammasome Complex Assembly	Positive Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Positive Regulation Of Autophagy Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Positive Regulation Of Macrophage Cytokine Production ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Cellular Response To Muramyl Dipeptide Xenophagy Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Xenophagy
Pathways		The NLRP1 inflammasome	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Migraine ( 27322543)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Knee osteoarthritis ( 27696742) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		10 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 MAPK14 NOD1 PYCARD	15 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 CFTR GABRB1 IRGM NLRP1 RIPK2 RNF34 SOX8 XIAP
Entrez ID		22861	10392
HPRD ID		07364	05815
Ensembl ID		ENSG00000091592	ENSG00000106100
Uniprot IDs		Q9C000	A0A024RA73 G3XAL1 Q9Y239
PDB IDs		1PN5 3KAT 4IFP 4IM6 5Y3S 6K7V 6X6C 6XKK 7WGE 8ZGD	2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Regulation Of Programmed Cell Death NLRP1 Inflammasome Complex Cellular Response To Stress Apoptotic Signaling Pathway Intracellular Signal Transduction Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Regulation Of Neuron Apoptotic Process Programmed Cell Death Involved In Cell Development Neuron Apoptotic Process Identical Protein Binding Protein Maturation Cysteine-type Peptidase Activity Signal Transduction Apoptosome Dendritic Cell Apoptotic Process AIM2 Inflammasome Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Signaling Pathway Protein-containing Complex Response To Virus Response To External Biotic Stimulus DNA Damage Response Pyroptotic Inflammatory Response Response To Stress Epithelial Cell Apoptotic Process Leukocyte Apoptotic Process Response To Mechanical Stimulus BH3 Domain Binding Positive Regulation Of Interleukin-1 Beta Production Response To Cytokine Positive Regulation Of Neuron Apoptotic Process Response To Peptide Osmosensory Signaling Pathway Positive Regulation Of Interleukin-1 Production NLRP3 Inflammasome Complex Cellular Response To Mechanical Stimulus Cytosol Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Response To Other Organism Cysteine-type Endopeptidase Activator Activity	Cell Death Apoptotic Process Programmed Cell Death CARD Domain Binding Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Defense Response Cysteine-type Endopeptidase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway NLRP1 Inflammasome Complex Activation Of Innate Immune Response Regulation Of Innate Immune Response Pyroptotic Inflammatory Response Cysteine-type Peptidase Activity Response To Lipid Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Defense Response To Bacterium Response To Lipopolysaccharide Regulation Of Defense Response Positive Regulation Of Innate Immune Response Protein Maturation Canonical Inflammasome Complex Response To Molecule Of Bacterial Origin Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cytokine-mediated Signaling Pathway Response To External Biotic Stimulus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Pyroptotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Stress Protein Processing Positive Regulation Of Interleukin-1 Production Response To Bacterium C-terminal Protein Lipidation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response Activation Of Immune Response Execution Phase Of Apoptosis Peptidase Activity Regulation Of Interleukin-1 Beta Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Proteolysis Protein Metabolic Process Regulation Of Interleukin-1 Production
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