PHLDA1 and KRTAP4-12

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PHLDA1	KRTAP4-12
Gene Name		pleckstrin homology-like domain, family A, member 1	keratin associated protein 4-12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane Cytoplasmic Vesicle Membrane	Keratin Filament
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Apoptotic Process Forebrain Neuron Differentiation Positive Regulation Of Apoptotic Process FasL Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494)
Protein-Protein Interactions		9 interactors: APP EIF3D HSPA4 HSPA4L KRTAP4-12 MDFI PABPC4 PLSCR1 RPL14	107 interactors: ADAMTSL4 ALPP AQP1 ATG12 ATN1 BAHD1 BEX2 C10orf62 C19orf66 CATSPER1 CBX2 CCDC116 CCDC185 CCNK CDC42EP1 CHCHD3 CHIC2 CLDN2 CNNM3 CNTFR COL8A1 CRCT1 CREB5 CRY1 DBF4B DLK2 EIF4E2 FAM107A FAM27E3 FAM76B FBXL18 FBXW5 GLRX3 GNE GPATCH2L GPRIN2 GRAP2 HHEX HOXA1 HOXB9 IFI30 ILF3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP3-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE1B LCE2D LCE3E LCE4A LINGO1 LNX1 MAPKBP1 MEOX2 MRPL4 NOTCH2NL NPDC1 NUDT18 NUFIP2 OTX1 PCSK5 PDGFRB PFKL PHLDA1 PLSCR1 PLSCR4 PNKP PRKAB2 PRR13 QPRT RERE RPS28 SLC25A10 SLC25A6 SMCP SPATA3 SPG7 SPRY2 TAP1 TBC1D16 TBC1D23 TCEB3B THAP10 THAP7 TOP3B TXNDC5 ZBTB16 ZNF165 ZNF20 ZNF250 ZNF408 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF581 ZNF638 ZNF655 ZNF764 ZSCAN26
Entrez ID		22822	83755
HPRD ID		05625	13941
Ensembl ID			ENSG00000213416
Uniprot IDs		Q8WV24	Q9BQ66
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stress Blood Coagulation Hemostasis Synaptic Growth At Neuromuscular Junction Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Body Fluid Levels Wound Healing Response To Unfolded Protein Collateral Sprouting In Absence Of Injury Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Translation Response To Wounding Protein Import Into Mitochondrial Outer Membrane RNA Catabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Platelet Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Phosphatidylserine Biosynthetic Process Axon Choice Point Recognition Membrane Organization Gene Expression Cytoplasmic Translational Initiation Translational Initiation Establishment Of Protein Localization To Membrane Neuron Remodeling Regulation Of Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Translation Phospholipid Scrambling Cytoplasmic Translation Chaperone-mediated Protein Complex Assembly Ribonucleoprotein Complex Biogenesis	Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Biosynthetic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Keratinization Anterior/posterior Pattern Specification Regulation Of Cellular Process Regulation Of Metabolic Process Cellular Process Keratinocyte Differentiation Embryo Development Phospholipid Scrambling Metanephric Glomerulus Vasculature Development Pattern Specification Process Metanephric Glomerulus Development Epidermal Cell Differentiation Epidermis Development Mitochondrion Organization Metabolic Process Forebrain Morphogenesis Transcription From RNA Polymerase II Promoter Glomerulus Vasculature Development Multicellular Organismal Development Organic Anion Transport Inner Ear Development Cell Migration Involved In Coronary Angiogenesis Hepatic Duct Development Abducens Nerve Formation Metanephric Mesenchymal Cell Migration Transepithelial Water Transport Renin Secretion Into Blood Stream Metanephric Descending Thin Limb Development DGDP Catabolic Process Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development
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