PHLDA1 and EIF3D

Number of citations of the paper that reports this interaction (PMID 11369516)
5

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PHLDA1	EIF3D
Gene Name		pleckstrin homology-like domain, family A, member 1	eukaryotic translation initiation factor 3, subunit D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane Cytoplasmic Vesicle Membrane	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Protein Binding	Translation Initiation Factor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Apoptotic Process Forebrain Neuron Differentiation Positive Regulation Of Apoptotic Process FasL Biosynthetic Process	Formation Of Translation Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways			Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494)
Protein-Protein Interactions		9 interactors: APP EIF3D HSPA4 HSPA4L KRTAP4-12 MDFI PABPC4 PLSCR1 RPL14	12 interactors: BEND5 DNAJB11 EIF3G EIF3J EIF3L EIF5 HOMER3 LZTS2 PHLDA1 REL SAT1 TRIM27
Entrez ID		22822	8664
HPRD ID		05625	04888
Ensembl ID			ENSG00000100353
Uniprot IDs		Q8WV24	B4DVY1 O15371
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stress Blood Coagulation Hemostasis Synaptic Growth At Neuromuscular Junction Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Body Fluid Levels Wound Healing Response To Unfolded Protein Collateral Sprouting In Absence Of Injury Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Translation Response To Wounding Protein Import Into Mitochondrial Outer Membrane RNA Catabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Platelet Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Phosphatidylserine Biosynthetic Process Axon Choice Point Recognition Membrane Organization Gene Expression Cytoplasmic Translational Initiation Translational Initiation Establishment Of Protein Localization To Membrane Neuron Remodeling Regulation Of Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Translation Phospholipid Scrambling Cytoplasmic Translation Chaperone-mediated Protein Complex Assembly Ribonucleoprotein Complex Biogenesis	Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Translational Initiation Regulation Of Translation Regulation Of Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Regulation Of Cellular Protein Metabolic Process Cellular Macromolecular Complex Assembly Translation Biosynthetic Process Cellular Macromolecule Biosynthetic Process Ribonucleoprotein Complex Biogenesis Macromolecule Biosynthetic Process FasL Biosynthetic Process Regulation Of Cellular Process Spermidine Acetylation Negative Regulation Of Interleukin-2 Secretion Cellular Component Assembly Putrescine Catabolic Process Cytokine Production Gene Expression Oxalate Transport Polyamine Catabolic Process Negative Regulation Of Calcium Ion Import 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Regulation Of Calcium Ion Transport Interferon-gamma Secretion Spindle Midzone Assembly Protein Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Neurotransmitter Uptake Microtubule Severing
Tagcloud ?			accomplishment alters arise checkpoint chronically cofilin deregulation description elav elusive g2 hdv hek hepatitis hepatocellular hspe interactor isotope manuscript mimic pathogenicity probable proteome proteomes proteomics pyruvate replication sigma transportin
Tagcloud (Difference) ?			accomplishment alters arise checkpoint chronically cofilin deregulation description elav elusive g2 hdv hek hepatitis hepatocellular hspe interactor isotope manuscript mimic pathogenicity probable proteome proteomes proteomics pyruvate replication sigma transportin
Tagcloud (Intersection) ?