PHLDA1 and KRTAP3-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHLDA1	KRTAP3-1
Description		pleckstrin homology like domain family A member 1	keratin associated protein 3-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoplasmic Vesicle	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding Phosphatidylinositol Phosphate Binding	Structural Molecule Activity Protein Binding
	Biological Process	Apoptotic Process Positive Regulation Of Apoptotic Process
Pathways		Interaction between PHLDA1 and AURKA MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Keratinization
Drugs
Diseases
GWAS		Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Atrial fibrillation ( 29892015 30061737) Blood trace element (Cu levels) ( 23720494) Blood urea nitrogen levels ( 29403010 31152163) Creatinine levels ( 29403010) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		43 interacting genes: APP CDPF1 CREBBP CYSRT1 EIF3D F2RL1 FBXO7 HSPA4 HSPA4L KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP5-1 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LGALS13 MDFI NBPF19 NOTCH2NLA PABPC4 PLSCR1 RPL14 TRAF4 TRAF6 TRIM42 TSPAN4	83 interacting genes: ADAM12 AGXT ANAPC11 BMP7 CDKN1A CELA2B CERK CFP CIMIP1 CNNM3 CREB5 CTRC CYSRT1 DMRT3 DOCK2 FAM168A FAM222B FOXH1 FRS3 GATA2 GNE GPS2 GSTP1 HCK HEY2 HOXB9 HR HSF4 IL16 ITGB4 KRTAP10-8 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP9-3 KRTAP9-8 LCE1B LCE2B LCE3A LCE3D LCE4A LCE5A LMO4 LRRC41 MAPKBP1 MRPL40 MYPOP NOTCH2NLA NTAQ1 OTX1 PATZ1 PCSK5 PHLDA1 PKIB PLSCR4 POLR1C PTPMT1 PVR RBPMS RECK REEP6 RNF44 SAMD7 SAXO4 SLC5A5 SMARCC1 SPAG8 SPMIP9 TEKT3 TLX3 TNS2 VASN VENTX VGLL3 WDR25 YPEL3 ZFHX2 ZNF414 ZNF446
Entrez ID		22822	83896
HPRD ID		05625	13937
Ensembl ID		ENSG00000139289	ENSG00000212901
Uniprot IDs		Q8WV24	Q9BYR8
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Cytosol Regulation Of JNK Cascade Positive Regulation Of JNK Cascade	Intermediate Filament Protein Binding Keratinization Keratin Filament Epidermis Development Axonemal A Tubule Inner Sheath Tissue Development Ventral Spinal Cord Interneuron Differentiation Heart Trabecula Morphogenesis Cellular Response To Cell-matrix Adhesion
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