PHLDA1 and LGALS13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHLDA1	LGALS13
Description		pleckstrin homology like domain family A member 1	galectin 13
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Body
	Molecular Function	Protein Binding Phosphatidylinositol Phosphate Binding	Phosphatidylcholine Lysophospholipase Activity Protein Binding Carbohydrate Binding
	Biological Process	Apoptotic Process Positive Regulation Of Apoptotic Process	Phospholipid Metabolic Process Apoptotic Process
Pathways		Interaction between PHLDA1 and AURKA MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Atrial fibrillation ( 29892015 30061737) Blood trace element (Cu levels) ( 23720494) Blood urea nitrogen levels ( 29403010 31152163) Creatinine levels ( 29403010) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Estimated glomerular filtration rate ( 30604766 31152163) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Lead levels ( 26025379)
Interacting Genes		43 interacting genes: APP CDPF1 CREBBP CYSRT1 EIF3D F2RL1 FBXO7 HSPA4 HSPA4L KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP5-1 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LGALS13 MDFI NBPF19 NOTCH2NLA PABPC4 PLSCR1 RPL14 TRAF4 TRAF6 TRIM42 TSPAN4	10 interacting genes: ACTB ACTG1 ANXA2 CREB5 HOXA1 NUFIP2 OTX1 PACSIN3 PHLDA1 POU4F2
Entrez ID		22822	29124
HPRD ID		05625	16375
Ensembl ID		ENSG00000139289	ENSG00000105198
Uniprot IDs		Q8WV24	Q9UHV8
PDB IDs			5XG7 5XG8 5Y03 6A62 6A63 6A64 6A65 6A66 6KJW 6KJX 6KJY
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Cytosol Regulation Of JNK Cascade Positive Regulation Of JNK Cascade	Positive Regulation Of Macromolecule Metabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Regulation Of Endocytosis DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Axonogenesis Regulation Of Synaptic Vesicle Endocytosis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Regulation Of Transcription By RNA Polymerase II Regulation Of Vesicle-mediated Transport DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleus Sequence-specific Double-stranded DNA Binding Platelet Aggregation Cell Projection Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Positive Regulation Of Transcription By RNA Polymerase II Semicircular Canal Formation Diencephalon Morphogenesis Homotypic Cell-cell Adhesion Negative Regulation Of Endocytosis Cytoskeletal Protein Binding Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Protein Localization To Cell Junction Regulation Of RNA Biosynthetic Process Regulation Of Norepinephrine Uptake Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
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