PHLDA1 and PABPC4

Number of citations of the paper that reports this interaction (PMID 11369516)
5

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PHLDA1	PABPC4
Gene Name		pleckstrin homology-like domain, family A, member 1	poly(A) binding protein, cytoplasmic 4 (inducible form)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane Cytoplasmic Vesicle Membrane	Nucleus Cytoplasm Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding Poly(A) RNA Binding
	Biological Process	Apoptotic Process Forebrain Neuron Differentiation Positive Regulation Of Apoptotic Process FasL Biosynthetic Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation
Pathways
Drugs
Diseases
GWAS		Blood trace element (Cu levels) ( 23720494)	C-reactive protein ( 21300955) HDL cholesterol ( 20686565)
Protein-Protein Interactions		9 interactors: APP EIF3D HSPA4 HSPA4L KRTAP4-12 MDFI PABPC4 PLSCR1 RPL14	14 interactors: EEF1A1 GDF9 HAP1 IL7R MED31 PHLDA1 RIF1 SETDB1 SMAD9 SREK1 SRPK2 UBC XRN1 YWHAQ
Entrez ID		22822	8761
HPRD ID		05625	04557
Ensembl ID			ENSG00000090621
Uniprot IDs		Q8WV24	B1ANR0 Q13310
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stress Blood Coagulation Hemostasis Synaptic Growth At Neuromuscular Junction Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Body Fluid Levels Wound Healing Response To Unfolded Protein Collateral Sprouting In Absence Of Injury Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Translation Response To Wounding Protein Import Into Mitochondrial Outer Membrane RNA Catabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Platelet Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Phosphatidylserine Biosynthetic Process Axon Choice Point Recognition Membrane Organization Gene Expression Cytoplasmic Translational Initiation Translational Initiation Establishment Of Protein Localization To Membrane Neuron Remodeling Regulation Of Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Translation Phospholipid Scrambling Cytoplasmic Translation Chaperone-mediated Protein Complex Assembly Ribonucleoprotein Complex Biogenesis	RNA Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Cellular Nitrogen Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Transcription, DNA-templated Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Transcription, DNA-templated Developmental Process Nitrogen Compound Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Death Multicellular Organismal Development Regulation Of Metabolic Process Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Cell Cycle Nuclear Speck Organization Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly FasL Biosynthetic Process Organ Development Brain Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway System Development BMP Signaling Pathway Head Development Regulation Of ERBB Signaling Pathway Midbrain Development Interleukin-7-mediated Signaling Pathway Oocyte Growth Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cilium Assembly
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