HIVEP3 and RUNX2

Number of citations of the paper that reports this interaction (PMID 16728642)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		HIVEP3	RUNX2
Gene Name		human immunodeficiency virus type I enhancer binding protein 3	runt-related transcription factor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Chromatin Nucleoplasm Transcription Factor Complex Cytoplasm
	Molecular Function	DNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Repressing Transcription Factor Binding
	Biological Process	Transcription, DNA-templated Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription, DNA-templated	Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Development Osteoblast Development Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Gene Expression T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Maturation Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways			Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS			Height ( 18391951) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		5 interactors: FHL1 RUNX2 TNFRSF1B TRAF1 TRAF2	36 interactors: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF XRCC5 XRCC6 YAP1
Entrez ID		59269	860
HPRD ID		09442	02566
Ensembl ID		ENSG00000127124	ENSG00000124813
Uniprot IDs		Q5T1R4	F8W8U5 Q13950 Q32MY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Tumor Necrosis Factor Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Death Death Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Homodimerization Activity Cellular Response To Nitric Oxide Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Osteoblast Fate Commitment Regulation Of Immunoglobulin Secretion RNA Destabilization Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Membrane Protein Ectodomain Proteolysis Response To Nitric Oxide Cytokine-mediated Signaling Pathway Regulation Of Odontogenesis Of Dentin-containing Tooth Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Regulation Of Protein Homodimerization Activity Cellular Response To Organic Substance Cellular Response To Reactive Nitrogen Species Regulation Of T Cell Cytokine Production Cellular Response To BMP Stimulus Activation Of NF-kappaB-inducing Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Osteoblast Development Regulation Of Potassium Ion Transmembrane Transporter Activity Response To Growth Factor Positive Regulation Of Potassium Ion Transport Regulation Of Odontogenesis Positive Regulation Of Chondrocyte Differentiation Immune System Process Positive Regulation Of NIK/NF-kappaB Signaling Protein K63-linked Ubiquitination Negative Regulation Of Smoothened Signaling Pathway Chondrocyte Development Protein Trimerization Regulation Of Proteolysis Positive Regulation Of Interleukin-2 Production Regulation Of Gene Expression Regulation Of Membrane Depolarization	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Response To Organic Substance Negative Regulation Of Transcription, DNA-templated Organ Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Cellular Metabolic Process Cellular Response To Stimulus Tissue Development Cellular Response To Stress System Development Regulation Of Cell Differentiation Response To Growth Factor Developmental Process Heart Development Positive Regulation Of Cell Differentiation Cardiovascular System Development Cell Differentiation Negative Regulation Of Signal Transduction
Tagcloud ?		alterations attracted candidates cdh13 chip coincided correlations date displaying disturbance epigenome explain h3k4me3 hpse2 il4r immunological inverse mcns microarray mononuclear nephrology nephrotic prkd2 probes q qrt trimethylation validate variations	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx3 syndromes unmethylated
Tagcloud (Difference) ?		alterations attracted candidates cdh13 chip coincided correlations date displaying disturbance epigenome explain h3k4me3 hpse2 il4r immunological inverse mcns microarray mononuclear nephrology nephrotic prkd2 probes q qrt trimethylation validate variations	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx3 syndromes unmethylated
Tagcloud (Intersection) ?