HIVEP3 and TNFRSF1B

Number of citations of the paper that reports this interaction (PubMedID 11804591)
0

Data Source:
HPRD (in vivo)

		HIVEP3	TNFRSF1B
Description		HIVEP zinc finger 3	TNF receptor superfamily member 1B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Plasma Membrane Membrane Specific Granule Membrane Membrane Raft
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Tumor Necrosis Factor Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Positive Regulation Of DNA-templated Transcription	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Pathways		Regulation of RUNX2 expression and activity	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs			Tasonermin
Diseases			Graft-versus-host disease
GWAS		Adult body size ( 32376654) Airway imaging phenotypes ( 26030696) Breast cancer ( 29059683) Bronchopulmonary dysplasia ( 23897914) Diastolic blood pressure ( 27618452) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) General risk tolerance (MTAG) ( 30643258) Gut microbiota (functional units) ( 27694959) Heel bone mineral density ( 30598549) High myopia ( 32428537) Intraocular pressure ( 29235454) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lupus nephritis in systemic lupus erythematosus ( 24925725) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418 27841878) Refractive error ( 32231278) Spatial memory ( 31596458) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418 27841878 27618452) Treatment resistant depression ( 30468137) White blood cell count ( 32888494)	Asthma ( 31959851) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		6 interacting genes: FHL1 GRSF1 RUNX2 TNFRSF1B TRAF1 TRAF2	21 interacting genes: BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 FOXP1 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420
Entrez ID		59269	7133
HPRD ID		09442	01862
Ensembl ID		ENSG00000127124	ENSG00000028137
Uniprot IDs		Q5T1R4	P20333
PDB IDs			1CA9 3ALQ 8HLB 9CU8
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex Tumor Necrosis Factor Binding Thioesterase Binding Tumor Necrosis Factor Receptor Binding Regulation Of T Cell Cytokine Production Ubiquitin Protein Ligase Binding Ligamentous Ossification Cytokine-mediated Signaling Pathway Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity TORC2 Complex Disassembly Regulation Of T Cell Mediated Immunity Positive Regulation Of DNA-binding Transcription Factor Activity TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Regulation Of Cytokine Production Involved In Immune Response Osteoblast Fate Commitment Positive Regulation Of Mitochondrial RNA Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Channel Activator Activity Potassium Channel Activator Activity Mitochondrial RNA Catabolic Process Membrane Raft Apoptotic Process Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Apoptotic Process Involved In Morphogenesis Negative Regulation Of Extracellular Matrix Constituent Secretion Aortic Valve Development Regulation Of RNA Stability Pulmonary Valve Development Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Intrinsic Apoptotic Signaling Pathway Glial Cell-neuron Signaling Regulation Of Lymphocyte Mediated Immunity Semi-lunar Valve Development Regulation Of Adaptive Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Sphingolipid Binding IRE1-TRAF2-ASK1 Complex CD27 Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Binding G-quadruplex RNA Binding Cell Death Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion	Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Cell Death Programmed Cell Death Regulation Of Immune Response Apoptotic Process Regulation Of Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Thioesterase Binding Regulation Of Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Signal Transduction Regulation Of Apoptotic Process Regulation Of Cytokine Production Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Chronic Inflammatory Response Aggresome Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Stress Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Proliferation Pattern Recognition Receptor Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Metabolic Process Immune Response-activating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Gene Expression Regulation Of Nitric Oxide Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Gene Expression
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