NDUFS6

Description		NADH:ubiquinone oxidoreductase subunit S6
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity
	Biological Process	Kidney Development Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Metabolic Process Muscle Contraction Mitochondrion Organization Aerobic Respiration Gene Expression Stem Cell Division Respiratory Electron Transport Chain DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial Respiratory Chain Complex I Assembly Multicellular Organism Growth Proton Motive Force-driven Mitochondrial ATP Synthesis Regulation Of Mitochondrial Membrane Potential Reproductive System Development Circulatory System Development Mesenchymal Stem Cell Differentiation Reactive Oxygen Species Metabolic Process Cellular Senescence Mesenchymal Stem Cell Proliferation Proton Transmembrane Transport
Pathways		Respiratory electron transport Complex I biogenesis
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Lack of perseverance ( 30718321) Metabolite levels ( 23823483)
Novel Interacting Genes		2 novel interacting genes: TAF1 TERT
Interacting Genes		5 interacting genes: FGFR3 KCNH2 MAP3K7 MAPK6 MAPK8IP2
Entrez ID		4726
HPRD ID		10356
Ensembl ID		ENSG00000145494
Uniprot IDs		O75380 Q6IBC4
PDB IDs		5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		MAPK Cascade Protein Kinase Activity MAP Kinase Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Intracellular Signaling Cassette Transferase Activity Positive Regulation Of Signaling Scaffold Protein Binding Protein Serine/threonine Kinase Activity Phosphorylation Protein Phosphorylation Protein Serine Kinase Activity Positive Regulation Of Androgen Receptor Signaling Pathway JNK Cascade Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Smooth Muscle Cell Migration Transcription Coactivator Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Kinase Binding Positive Regulation Of Smooth Muscle Cell Proliferation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Heart Rate By Hormone Septin Cytoskeleton Negative Regulation Of Protein Autoubiquitination Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex ATP Binding Bone Maturation Regulation Of Biological Quality Negative Regulation Of Signal Transduction Cellular Response To Hypoxia I-kappaB Phosphorylation Linear Polyubiquitin Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity Cellular Response To Decreased Oxygen Levels Positive Regulation Of Phospholipase Activity Regulation Of Protein Modification Process
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