NDUFS6 and KCNH2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NDUFS6	KCNH2
Gene Name		NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)	potassium channel, voltage gated eag related subfamily H, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I	Nuclear Envelope Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity Electron Carrier Activity	Phosphorelay Sensor Kinase Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Metabolic Process Muscle Contraction Multicellular Organismal Aging Respiratory Electron Transport Chain Multicellular Organism Growth Cellular Metabolic Process Small Molecule Metabolic Process Reproductive System Development Mitochondrion Morphogenesis Cardiovascular System Development	Phosphorelay Signal Transduction System Regulation Of Heart Rate By Hormone Synaptic Transmission Signal Transduction By Phosphorylation Cellular Response To Drug Regulation Of Membrane Potential Potassium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport	Potassium Channels Voltage gated Potassium channels
Drugs		NADH	Dofetilide Amsacrine Ibutilide Terfenadine Prazosin Sotalol Doxazosin Cisapride Astemizole Verapamil Thioridazine Quinidine Pimozide Miconazole Amiodarone Carvedilol Terazosin Propafenone Halofantrine Dronedarone Sertindole
Diseases
GWAS			Electrocardiographic traits ( 20062061 20062063) QT interval ( 23166209 19305408 19305409)
Protein-Protein Interactions		5 interactors: FGFR3 KCNH2 MAP3K7 MAPK6 MAPK8IP2	10 interactors: ALG10 ALG10B CDC73 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH
Entrez ID		4726	3757
HPRD ID		10356	01069
Ensembl ID			ENSG00000055118
Uniprot IDs		O75380 Q6IBC4	Q12809 Q15BH2
PDB IDs			1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 4HP9 4HQA
Enriched GO Terms of Interacting Partners?		Signal Transduction By Phosphorylation MAPK Cascade Phosphorylation Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity JNK Cascade Regulation Of MAPK Cascade Negative Regulation Of Potassium Ion Export Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Membrane Depolarization Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Regulation Of Heart Rate By Hormone Positive Regulation Of Phosphorylation Regulation Of JNK Cascade Positive Regulation Of Protein Modification Process Cell-cell Signaling Signal Transduction Peptidyl-amino Acid Modification Regulation Of Stress-activated MAPK Cascade Signaling Regulation Of Protein Phosphorylation Cell Communication Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Nonassociative Learning Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Alveolar Secondary Septum Development Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Membrane Potential Axonogenesis Involved In Innervation Positive Regulation Of Signal Transduction Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Phosphorylation Defense Response Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Cellular Response To Stimulus Chondrocyte Proliferation Peptidyl-histidine Phosphorylation	Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cardiac Conduction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Regulation Of Heart Rate Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Striated Muscle Contraction Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein N-linked Glycosylation Ventricular Cardiac Muscle Cell Action Potential Regulation Of Muscle Contraction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Positive Regulation Of Intracellular Transport Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Transport Dolichol-linked Oligosaccharide Biosynthetic Process Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Protein Glycosylation Macromolecule Glycosylation Glycosylation Apoptotic Signaling Pathway Glucocorticoid Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Glycoprotein Biosynthetic Process Midbrain Development Carbohydrate Metabolic Process Regulation Of Intracellular Transport
Tagcloud ?		abnormality albuminuria cystatin defects defence deficiency electrochemical excretion f2t glomerular gt hallmarks impairment inner innovation interruption isoprostane juvenile kim mitochondrial modest nitrotyrosine oxidized partial renal respiratory se superoxide	1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Difference) ?		abnormality albuminuria cystatin defects defence deficiency electrochemical excretion f2t glomerular gt hallmarks impairment inner innovation interruption isoprostane juvenile kim mitochondrial modest nitrotyrosine oxidized partial renal respiratory se superoxide	1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Intersection) ?