NDUFS6 and KCNH2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NDUFS6	KCNH2
Description		NADH:ubiquinone oxidoreductase subunit S6	potassium voltage-gated channel subfamily H member 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex
	Molecular Function	NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity	Transcription Cis-regulatory Region Binding Monoatomic Ion Channel Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Kidney Development Mitochondrial Electron Transport, NADH To Ubiquinone Fatty Acid Metabolic Process Muscle Contraction Mitochondrion Organization Aerobic Respiration Gene Expression Stem Cell Division Respiratory Electron Transport Chain DNA Damage Response, Signal Transduction By P53 Class Mediator Mitochondrial Respiratory Chain Complex I Assembly Multicellular Organism Growth Proton Motive Force-driven Mitochondrial ATP Synthesis Regulation Of Mitochondrial Membrane Potential Reproductive System Development Circulatory System Development Mesenchymal Stem Cell Differentiation Reactive Oxygen Species Metabolic Process Cellular Senescence Mesenchymal Stem Cell Proliferation Proton Transmembrane Transport	Regulation Of Heart Rate By Hormone Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of DNA-templated Transcription Potassium Ion Homeostasis Transmembrane Transport Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Monoatomic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		Respiratory electron transport Complex I biogenesis	Voltage gated Potassium channels Phase 3 - rapid repolarisation
Drugs		NADH	Fluvoxamine Erythromycin Dofetilide Enflurane Phenytoin Amsacrine Disopyramide Ibutilide Amitriptyline Terfenadine Loratadine Prazosin Imipramine Fluoxetine Chlorpromazine Sotalol Ciprofloxacin Hydroxyzine Doxazosin Cisapride Astemizole Verapamil Tamoxifen Thioridazine Loperamide Quinidine Ketoconazole Procainamide Promethazine Perhexiline Pimozide Miconazole Amiodarone Carvedilol Doxepin Nefazodone Terazosin Propafenone Flecainide Clarithromycin Halofantrine Bepridil Vanoxerine Dronedarone Azimilide Sertindole Silodosin Vernakalant Tecastemizole Potassium nitrate Pentoxyverine Chlorobutanol Isavuconazole Pitolisant
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Short QT syndrome Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Lack of perseverance ( 30718321) Metabolite levels ( 23823483)	Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) Body fat distribution (arm fat ratio) ( 30664634) Body mass index ( 29273807) Chronotype ( 30696823) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 20062061) Electrocardiographic traits (multivariate) ( 32602732) Eyebrow thickness ( 26926045) Metabolic syndrome ( 31589552) QT interval ( 29213071 29874175 24952745 23166209 30679814 19305409 19305408) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560)
Interacting Genes		5 interacting genes: FGFR3 KCNH2 MAP3K7 MAPK6 MAPK8IP2	11 interacting genes: ALG10 ALG10B CDC73 FRMD8 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH
Entrez ID		4726	3757
HPRD ID		10356	01069
Ensembl ID		ENSG00000145494	ENSG00000055118
Uniprot IDs		O75380 Q6IBC4	A0A090N7W1 A0A090N7X5 A0A090N8Q0 A0AAQ5BGQ9 Q12809 Q15BH2
PDB IDs		5XTB 5XTD 5XTH 5XTI	1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 2N7G 4HP9 4HQA 5VA1 5VA2 5VA3 6SYG 8IO4 8IO5 8IOB 8ZYN 8ZYO 8ZYP 8ZYQ 9CHP 9CHQ 9CHR 9CHS
Enriched GO Terms of Interacting Partners?		MAPK Cascade Protein Kinase Activity MAP Kinase Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Intracellular Signaling Cassette Transferase Activity Positive Regulation Of Signaling Scaffold Protein Binding Protein Serine/threonine Kinase Activity Phosphorylation Protein Phosphorylation Protein Serine Kinase Activity Positive Regulation Of Androgen Receptor Signaling Pathway JNK Cascade Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Smooth Muscle Cell Migration Transcription Coactivator Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Kinase Binding Positive Regulation Of Smooth Muscle Cell Proliferation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Heart Rate By Hormone Septin Cytoskeleton Negative Regulation Of Protein Autoubiquitination Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex ATP Binding Bone Maturation Regulation Of Biological Quality Negative Regulation Of Signal Transduction Cellular Response To Hypoxia I-kappaB Phosphorylation Linear Polyubiquitin Binding RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA-directed DNA Polymerase Activity Cellular Response To Decreased Oxygen Levels Positive Regulation Of Phospholipase Activity Regulation Of Protein Modification Process	Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate Dolichyl Pyrophosphate Glc2Man9GlcNAc2 Alpha-1,2-glucosyltransferase Activity Membrane Repolarization Transmembrane Transporter Binding Regulation Of Membrane Repolarization Regulation Of Metal Ion Transport Regulation Of Heart Rate By Cardiac Conduction Potassium Channel Regulator Activity Regulation Of Monoatomic Ion Transport Cardiac Conduction Regulation Of Membrane Potential Regulation Of Heart Contraction Neural Nucleus Development Negative Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Monoatomic Ion Transport Potassium Ion Export Across Plasma Membrane Negative Regulation Of Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Intracellular Potassium Ion Homeostasis Dolichol-linked Oligosaccharide Biosynthetic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Multicellular Organismal Process Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Negative Regulation Of Transporter Activity Negative Regulation Of Potassium Ion Transport Cardiac Muscle Cell Action Potential Involved In Contraction Potassium Ion Homeostasis Regulation Of Protein Export From Nucleus Cardiac Muscle Cell Action Potential Regulation Of System Process Regulation Of Biological Quality Protein Domain Specific Binding Substantia Nigra Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?