HNRNPL and PCBP2

Number of citations of the paper that reports this interaction (PMID 10772858)
48

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, two hybrid)

		HNRNPL	PCBP2
Gene Name		heterogeneous nuclear ribonucleoprotein L	poly(rC) binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Ribonucleoprotein Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Membrane Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding	DNA Binding RNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing Gene Expression	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression MRNA Metabolic Process Negative Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Defense Response To Virus Defense Response To Virus
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Negative regulators of RIG-I/MDA5 signaling mRNA Splicing - Major Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APEX1 CSE1L CSNK2A1 FGFR3 HIST3H3 HMG20B HMGA1 HNRNPA2B1 HNRNPK IL7R ITCH NEDD4 PCBP2 PJA1 PTBP1 SUMO4	25 interactors: BARD1 CASK CNBP FLNA HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL NKAP PABPC1 PAXIP1 PCBP1 PRPF40A PTBP1 QKI SF3B2 SLU7 SNRPA SRSF3 SRSF7 WDR77 WDR83 YBX1 YBX3
Entrez ID		3191	5094
HPRD ID		04360	03129
Ensembl ID		ENSG00000104824	ENSG00000197111
Uniprot IDs		P14866 Q6NTA2	B4DXP5 F8VZX2 G3V0E8 Q15366
PDB IDs		3R27 3TO8	2AXY 2JZX 2P2R 2PQU 2PY9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing Negative Regulation Of RNA Splicing Regulation Of RNA Metabolic Process Negative Regulation Of Defense Response To Virus MRNA Processing Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Cellular Metabolic Process MRNA Metabolic Process Positive Regulation Of Protein Catabolic Process Viral Process Negative Regulation Of Type I Interferon Production RNA Processing RNA Metabolic Process Negative Regulation Of Mitotic Nuclear Division Protein Modification By Small Protein Conjugation Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Response To Virus Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Transmission Of Virus Development Involved In Symbiotic Interaction Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Gene Expression Base-excision Repair Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Immune Response Telomere Maintenance Negative Regulation Of Gene Expression Negative Regulation Of Cell Division Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Interleukin-7-mediated Signaling Pathway Oncogene-induced Cell Senescence Regulation Of Defense Response To Virus Negative Regulation Of Biosynthetic Process	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Gene Expression Posttranscriptional Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated Oncogene-induced Cell Senescence Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of MRNA Processing MRNA Stabilization Regulation Of Nitrogen Compound Metabolic Process Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Gene Expression Positive Regulation Of Cellular Senescence Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Aging Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translation Heterochromatin Assembly Biosynthetic Process MRNA 3'-end Processing Heterochromatin Organization Positive Regulation Of Cellular Metabolic Process Regulation Of MRNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Translation
Tagcloud ?			9b aip4 atg5 clue coronaviruses cov depended dynamin etiologic evade evades fission havoc hect illustrates localizes manipulates mavs mitochondria orf outbreak proteasomal sars signalosome traf traf3 triggering uncovered usurping
Tagcloud (Difference) ?			9b aip4 atg5 clue coronaviruses cov depended dynamin etiologic evade evades fission havoc hect illustrates localizes manipulates mavs mitochondria orf outbreak proteasomal sars signalosome traf traf3 triggering uncovered usurping
Tagcloud (Intersection) ?