HBZ and RBMY1A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HBZ	RBMY1A1
Description		hemoglobin subunit zeta	RNA binding motif protein Y-linked family 1 member A1
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GO Annotations	Cellular Component	Hemoglobin Complex Haptoglobin-hemoglobin Complex Extracellular Exosome	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus
	Molecular Function	Oxygen Carrier Activity Iron Ion Binding Protein Binding Oxygen Binding Heme Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Carbon Dioxide Transport Oxygen Transport Erythrocyte Maturation Erythrocyte Development	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Early cardiac repolarization ( 31600170) Hemoglobin ( 32888494) Hemoglobin levels ( 26366553) Mean corpuscular hemoglobin ( 27863252 29403010 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 27863252 29403010) Red blood cell count ( 29403010 32888494)
Interacting Genes		30 interacting genes: APP CARD10 CCNDBP1 CYSRT1 DOCK8 FGFR3 GOLGA6L9 HBB HBD HBE1 HBG2 HBM HBQ1 HNRNPD HNRNPK IKBKG KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 MTUS2 NBPF19 NOTCH2NLA NTAQ1 RBMY1A1 SP1 UPF2	29 interacting genes: AEN APOBEC3C CBX2 CIRBP CLK3 DAAM2 DHX57 HBZ HNRNPK KHDRBS3 LMNTD2 LNX1 MYPOP PCDHB14 PRPF31 PRR3 RASD1 RBM3 RBMX RBMY1F RBMY1J SNRPA SRSF3 SRSF9 TERF1 TH TRA2B YTHDC1 ZNF317
Entrez ID		3050	5940
HPRD ID		00794	02450
Ensembl ID		ENSG00000130656	ENSG00000234414
Uniprot IDs		P02008	P0DJD3
PDB IDs		1JEB 3W4U	2FY1
Enriched GO Terms of Interacting Partners?		Hemoglobin Complex Haptoglobin-hemoglobin Complex Oxygen Carrier Activity Oxygen Transport Oxygen Binding Erythrocyte Development Myeloid Cell Development Hemoglobin Alpha Binding Carbon Dioxide Transport Hemopoiesis Heme Binding One-carbon Compound Transport Keratin Filament Intermediate Filament Regulation Of MRNA Splicing, Via Spliceosome Blood Microparticle MRNA Binding Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Cell Development Positive Regulation Of Amyloid Precursor Protein Catabolic Process Telomeric DNA Binding	Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing Nucleic Acid Binding Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Binding MRNA Processing Positive Regulation Of RNA Splicing RNA Splicing RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Metabolic Process Positive Regulation Of MRNA Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Primary Metabolic Process Negative Regulation Of RNA Splicing Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of MRNA Metabolic Process Protein Domain Specific Binding Nucleoplasm Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Pre-mRNA Binding Negative Regulation Of Macromolecule Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Gene Expression Nuclear Speck Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere
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