ZNRF2 and AKTIP

Number of citations of the paper that reports this interaction (PubMedID 32265276)
0

Data Source:
BioGRID (two hybrid)

		ZNRF2	AKTIP
Description		zinc and ring finger 2	AKT interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Protein-containing Complex Presynaptic Membrane Cell Projection Intracellular Membrane-bounded Organelle Synapse	Nucleus Cytoplasm Plasma Membrane Membrane HOPS Complex FHF Complex
	Molecular Function	Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Intracellular Potassium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Autophagosome-lysosome Fusion	Positive Regulation Of Protein Phosphorylation Postreplication Repair Apoptotic Process Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein K63-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Cadmium levels ( 26025379)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412 34021172) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		16 interacting genes: AKTIP ATP1A1 MTOR PPP6C UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2T UBE2V1 UBE2W	35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS28 VPS41 ZNRF2
Entrez ID		223082	64400
HPRD ID		15894	07467
Ensembl ID		ENSG00000180233	ENSG00000166971
Uniprot IDs		A0A090N8Y8 Q8NHG8	Q9H8T0
PDB IDs			8QAT
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K48-linked Ubiquitination Protein Monoubiquitination Protein K63-linked Ubiquitination Protein Modification Process Protein K11-linked Ubiquitination Protein Metabolic Process ATP Binding Modification-dependent Protein Catabolic Process Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Macromolecule Metabolic Process Macromolecule Catabolic Process DNA Damage Response Proteolysis TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination TOR Signaling Negative Regulation Of TOR Signaling Protein K6-linked Ubiquitination Regulation Of TORC1 Signaling Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Cellular Response To Stress DNA Repair Postreplication Repair ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of TOR Signaling ISG15-protein Conjugation Nucleoplasm Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein K63-linked Ubiquitination DNA Metabolic Process Protein Autoubiquitination Nucleus Protein K29-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Cellular Response To Nutrient Levels Protein K27-linked Ubiquitination	HOPS Complex Endosome To Lysosome Transport FHF Complex Intracellular Protein Localization Protein Transport Vacuolar Transport Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Transport Lysosomal Transport Establishment Of Protein Localization Cellular Localization Endosome Organization Intracellular Protein Transport Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Vesicle Organization Lysosome Organization Cytoplasmic Microtubule Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Localization To Organelle Identical Protein Binding Cellular Response To Laminar Fluid Shear Stress Organelle Organization Response To Laminar Fluid Shear Stress Vesicle-mediated Transport Endosomal Transport Endosome Membrane Dynein Light Intermediate Chain Binding CGAS/STING Signaling Pathway Membrane Organization Cellular Response To Fluid Shear Stress Establishment Of Protein Localization To Organelle Ubiquitin Protein Ligase Activity CORVET Complex Response To Fluid Shear Stress Protein Import Into Nucleus Positive Regulation Of CGAS/STING Signaling Pathway Import Into Nucleus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Nuclear Transport Nucleocytoplasmic Transport Protein Ubiquitination AP-3 Adaptor Complex Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Anoikis Microtubule Cytoskeleton Organization Late Endosome Membrane
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