ZNRF2 and UBE2T

Number of citations of the paper that reports this interaction (PubMedID 32265276)
0

Data Source:
BioGRID (two hybrid)

		ZNRF2	UBE2T
Description		zinc and ring finger 2	ubiquitin conjugating enzyme E2 T
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Protein-containing Complex Presynaptic Membrane Cell Projection Intracellular Membrane-bounded Organelle Synapse	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Intracellular Potassium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Autophagosome-lysosome Fusion	Protein Polyubiquitination DNA Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Fanconi Anemia Pathway Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Cadmium levels ( 26025379)	Breast cancer ( 23535733) Celiac disease ( 23936387)
Interacting Genes		16 interacting genes: AKTIP ATP1A1 MTOR PPP6C UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2T UBE2V1 UBE2W	25 interacting genes: AMFR ARIH2 BRCA1 CDK2 CHEK1 FANCD2 FANCL LNX2 MARCHF5 MGRN1 PCGF2 PRKCG PRKN RNF128 RNF144B RNF167 RNF31 RNF4 ROCK1 RPS6KA1 TRIM27 UBA1 UBA6 UBC ZNRF2
Entrez ID		223082	29089
HPRD ID		15894	13704
Ensembl ID		ENSG00000180233	ENSG00000077152
Uniprot IDs		A0A090N8Y8 Q8NHG8	Q9NPD8
PDB IDs			1YH2 4CCG 5NGZ 5OJJ 6R75 7KZR 7KZS 7KZT 7KZV 8JUC 8JVD 8JVE 8JVL
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K48-linked Ubiquitination Protein Monoubiquitination Protein K63-linked Ubiquitination Protein Modification Process Protein K11-linked Ubiquitination Protein Metabolic Process ATP Binding Modification-dependent Protein Catabolic Process Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Macromolecule Metabolic Process Macromolecule Catabolic Process DNA Damage Response Proteolysis TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination TOR Signaling Negative Regulation Of TOR Signaling Protein K6-linked Ubiquitination Regulation Of TORC1 Signaling Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Cellular Response To Stress DNA Repair Postreplication Repair ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of TOR Signaling ISG15-protein Conjugation Nucleoplasm Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein K63-linked Ubiquitination DNA Metabolic Process Protein Autoubiquitination Nucleus Protein K29-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Cellular Response To Nutrient Levels Protein K27-linked Ubiquitination	Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Transferase Activity Protein Polyubiquitination Protein Metabolic Process Zinc Ion Binding Metal Ion Binding Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Autoubiquitination Protein K6-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Response To Stress Cellular Response To Stress Protein K27-linked Ubiquitination Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Cytosol Ubiquitin Activating Enzyme Activity DNA Damage Response DNA Damage Checkpoint Signaling Ubiquitin Conjugating Enzyme Binding Condensed Chromosome Negative Regulation Of Programmed Cell Death Regulation Of Organelle Organization Catabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Protein Monoubiquitination Cytoplasm Ubiquitin-like Modifier Activating Enzyme Activity Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Autophagy Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Protein K29-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling
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