ZNRF2

Gene Name		zinc and ring finger 2, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Plasma Membrane Endosome Membrane Cell Junction Cytoplasmic Vesicle Membrane Presynaptic Membrane
	Molecular Function	Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N
Entrez ID		223082
HPRD ID		15894
Ensembl ID		ENSG00000180233
Uniprot IDs		Q8NHG8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Protein Catabolic Process Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Macromolecule Catabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Ubiquitination Proteolysis Cellular Protein Modification Process Positive Regulation Of Immune Response Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Regulation Of Chromosome Organization Catabolic Process Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Immune Response Protein K63-linked Ubiquitination Positive Regulation Of Immune System Process Mitotic Spindle Assembly Checkpoint Histone Ubiquitination Spindle Assembly Checkpoint Response To Hypoxia Mitotic Spindle Checkpoint Cellular Protein Metabolic Process
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