ZNRF2 and PPP6C

Number of citations of the paper that reports this interaction (PubMedID 27244671)
42

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		ZNRF2	PPP6C
Description		zinc and ring finger 2	protein phosphatase 6 catalytic subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Protein-containing Complex Presynaptic Membrane Cell Projection Intracellular Membrane-bounded Organelle Synapse	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Protein Ubiquitination Intracellular Potassium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Autophagosome-lysosome Fusion	G1/S Transition Of Mitotic Cell Cycle Immune System Process Protein Dephosphorylation Innate Immune Response COPII Vesicle Coating CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Telomere Extension By Telomerase COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Cadmium levels ( 26025379)	Pulse pressure ( 27841878) Refractive error ( 32231278) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		16 interacting genes: AKTIP ATP1A1 MTOR PPP6C UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2T UBE2V1 UBE2W	7 interacting genes: AURKA IGBP1 NFKBIE TGFBR1 TIPRL VAC14 ZNRF2
Entrez ID		223082	5537
HPRD ID		15894	02141
Ensembl ID		ENSG00000180233	ENSG00000119414
Uniprot IDs		A0A090N8Y8 Q8NHG8	A0A024R861 O00743
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein K48-linked Ubiquitination Protein Monoubiquitination Protein K63-linked Ubiquitination Protein Modification Process Protein K11-linked Ubiquitination Protein Metabolic Process ATP Binding Modification-dependent Protein Catabolic Process Nucleotide Binding Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Macromolecule Metabolic Process Macromolecule Catabolic Process DNA Damage Response Proteolysis TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination TOR Signaling Negative Regulation Of TOR Signaling Protein K6-linked Ubiquitination Regulation Of TORC1 Signaling Regulation Of Protein Polyubiquitination UBC13-MMS2 Complex Cellular Response To Stress DNA Repair Postreplication Repair ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of TOR Signaling ISG15-protein Conjugation Nucleoplasm Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein K63-linked Ubiquitination DNA Metabolic Process Protein Autoubiquitination Nucleus Protein K29-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Cellular Response To Nutrient Levels Protein K27-linked Ubiquitination	Peptidyl-serine Phosphorylation
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