ALKBH3 and GLRX3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ALKBH3	GLRX3
Description		alkB homolog 3, alpha-ketoglutarate dependent dioxygenase	glutaredoxin 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Cytosol Cell Cortex Z Disc Dendrite Iron-sulfur Cluster Assembly Complex
	Molecular Function	Protein Binding Ferrous Iron Binding Oxidoreductase Activity L-ascorbic Acid Binding Oxidative RNA Demethylase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity MRNA N1-methyladenosine Dioxygenase Activity	RNA Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding
	Biological Process	DNA Repair DNA Alkylation Repair DNA Damage Response Cell Population Proliferation Negative Regulation Of Cytoplasmic Translation	Regulation Of The Force Of Heart Contraction Intracellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly Cell Redox Homeostasis
Pathways		ALKBH3 mediated reversal of alkylation damage	Iron uptake and transport
Drugs		Ascorbic acid
Diseases
GWAS		Chronotype ( 30696823) Femur bone mineral density x serum urate levels interaction ( 34046847) Morning person ( 30696823)	Alcohol dependence ( 26365420) Colorectal cancer ( 34062886) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Mean corpuscular volume ( 32888494) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Sleep end time ( 33075057) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		13 interacting genes: AK8 FBXO7 GLRX3 GOLGA2 GSK3A IKZF1 LNX1 OTUD4 SRPK1 SRPK2 TRIM55 TRIM63 ZDHHC17	99 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CEBPA CERCAM CGGBP1 CIAPIN1 COL8A1 DANCR EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ RCOR3 RECK RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774
Entrez ID		221120	10539
HPRD ID		16793	10153
Ensembl ID		ENSG00000166199	ENSG00000108010
Uniprot IDs		Q96Q83	A0A140VJK1 O76003
PDB IDs		2IUW 8JNK 8JNR 9NCZ	2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?		Protein Modification Process Protein Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Transferase Activity Regulation Of Cardiac Muscle Hypertrophy Protein Ubiquitination Innate Immune Response Protein Modification By Small Protein Conjugation Cytoplasm Defense Response To Other Organism Immune System Process Defense Response To Symbiont Positive Regulation Of Viral Genome Replication Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Perforant Pathway To Dendrate Granule Cell Synapse Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Muscle System Process Regulation Of Neuron Apoptotic Process Ubiquitin-protein Transferase Activity Kinase Activity Response To Other Organism Positive Regulation Of Viral Process Identical Protein Binding Regulation Of Carbohydrate Catabolic Process Protein Polyubiquitination Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Viral Genome Replication Immune Response Negative Regulation Of Viral Process Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Microtubule Response To External Biotic Stimulus Protein Serine Kinase Activity Lewy Body Core Regulation Of Protein K48-linked Deubiquitination	Intermediate Filament Keratin Filament Hair Cycle Iron-sulfur Cluster Assembly Protein Binding Iron-sulfur Cluster Assembly Complex Identical Protein Binding
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