ISCU and CCDC172

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ISCU	CCDC172
Description		iron-sulfur cluster assembly enzyme	coiled-coil domain containing 172
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex	Cytoplasm Cilium Cell Projection Sperm Midpiece
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding Molecular Adaptor Activity Iron-sulfur Cluster Chaperone Activity	Protein Binding
	Biological Process	Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Iron Ion Import Across Plasma Membrane
Pathways		Maturation of replicase proteins
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Intraocular pressure ( 29617998)	Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Malaria ( 31844061) Severe autoimmune type 2 diabetes ( 34737425)
Interacting Genes		17 interacting genes: AGTRAP BANP CBY2 CCDC136 CCDC172 FAM9B GOLGA2 GOLGA6L9 HPRT1 IKZF1 KRT34 KRT40 LNX1 MID2 NECAB2 NUP62 PICK1	20 interacting genes: CATSPERT DCTN2 FAM13C FAM161B HDDC3 ISCU KDM1A MRPL11 MSGN1 NEFL PCDHB12 PLEKHF2 PRKAA2 PSTPIP1 SH2D4A SMARCE1 TCHP TEAD4 TXNDC9 VPS9D1
Entrez ID		23479	374355
HPRD ID		14828	18604
Ensembl ID		ENSG00000136003	ENSG00000182645
Uniprot IDs		B1P7G3 B3KQ30 B4DNC9 Q9H1K1	P0C7W6
PDB IDs		5KZ5 5WKP 5WLW 6NZU 6UXE 6W1D 6WI2 6WIH 7RTK 8PK8 8PK9 8PKA 8RMC 8RMD 8RME 8RMF 8RMG 8TVT
Enriched GO Terms of Interacting Partners?		Identical Protein Binding
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