ISCU and HPRT1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ISCU	HPRT1
Description		iron-sulfur cluster assembly enzyme	hypoxanthine phosphoribosyltransferase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Iron Ion Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Protein Homodimerization Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding Molecular Adaptor Activity Iron-sulfur Cluster Chaperone Activity	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Identical Protein Binding Metal Ion Binding Guanine Phosphoribosyltransferase Activity
	Biological Process	Intracellular Iron Ion Homeostasis Iron-sulfur Cluster Assembly [2Fe-2S] Cluster Assembly [4Fe-4S] Cluster Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Iron Ion Import Across Plasma Membrane	T Cell Mediated Cytotoxicity Response To Amphetamine Purine Nucleotide Biosynthetic Process Purine Ribonucleoside Salvage Guanine Salvage Grooming Behavior Locomotory Behavior Striatum Development Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Development GMP Salvage IMP Salvage Dopamine Metabolic Process Hypoxanthine Salvage AMP Salvage Positive Regulation Of Dopamine Metabolic Process GMP Catabolic Process IMP Metabolic Process Adenine Metabolic Process Hypoxanthine Metabolic Process Lymphocyte Proliferation Dendrite Morphogenesis Protein Homotetramerization Dopaminergic Neuron Differentiation
Pathways		Maturation of replicase proteins	Purine salvage Defective HPRT1 disrupts guanine and hypoxanthine salvage Azathioprine ADME
Drugs			Mercaptopurine 5-O-phosphono-alpha-D-ribofuranosyl diphosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine 3H-pyrazolo[4,3-d]pyrimidin-7-ol 9-Deazaguanine
Diseases			Lesch-Nyhan syndrome; Hypoxanthine-guanine phosophoribosyltransferase deficiency
GWAS		Acne (severe) ( 24927181) Intraocular pressure ( 29617998)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		17 interacting genes: AGTRAP BANP CBY2 CCDC136 CCDC172 FAM9B GOLGA2 GOLGA6L9 HPRT1 IKZF1 KRT34 KRT40 LNX1 MID2 NECAB2 NUP62 PICK1	11 interacting genes: CEBPA EEF2KMT EFCAB3 FANCA GNMT ISCU NTAQ1 PRTFDC1 SDCBP SPG21 SREK1IP1
Entrez ID		23479	3251
HPRD ID		14828	02388
Ensembl ID		ENSG00000136003	ENSG00000165704
Uniprot IDs		B1P7G3 B3KQ30 B4DNC9 Q9H1K1	A0A140VJL3 P00492
PDB IDs		5KZ5 5WKP 5WLW 6NZU 6UXE 6W1D 6WI2 6WIH 7RTK 8PK8 8PK9 8PKA 8RMC 8RMD 8RME 8RMF 8RMG 8TVT	1BZY 1D6N 1HMP 1Z7G 2VFA 3GEP 3GGC 3GGJ 4IJQ 4KN6 4RAB 4RAC 4RAD 4RAN 4RAO 4RAQ 5BRN 5BSK 5HIA 5W8V 6BNJ 7SAN 8TPY
Enriched GO Terms of Interacting Partners?		Identical Protein Binding	Purine Nucleoside Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Negative Regulation Of Iron Ion Import Across Plasma Membrane Iron-sulfur Cluster Chaperone Activity Negative Regulation Of Iron Ion Transmembrane Transport Sarcosine Metabolic Process Nucleoside Metabolic Process Glycine N-methyltransferase Activity S-adenosylhomocysteine Metabolic Process Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?