LCE1C and KRTAP2-4

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		LCE1C	KRTAP2-4
Description		late cornified envelope 1C	keratin associated protein 2-4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Epidermis Development Keratinization
Pathways		Formation of the cornified envelope	Keratinization Keratinization
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		75 interacting genes: ADAMTSL4 ALPP CHIC2 CHRD CRCT1 CREB5 CYSRT1 EFEMP1 EFEMP2 FBLN1 GUCD1 HOXA1 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE4A LCE5A MACO1 NECTIN2 NTAQ1 NTN4 NUTF2 ODF1 OIT3 OTX1 PLA2G10 PLAC8 PLSCR3 PLSCR4 POU4F2 PSMB1 SLC39A7 SPRED2 SPRY1 SPRY2 TGFB1 TRIM42 VASN VWC2 VWC2L	100 interacting genes: ADAMTSL3 BAHD1 BCL6B BEX2 C11orf87 CATSPER1 CBX2 CHIC2 CNNM3 CREB5 CTSZ CXCL16 CYSRT1 DHX57 DMRT3 FAM161A GEMIN4 GGN HAPLN2 HHEX HOXA1 HOXB9 IGSF8 ITGB4 JOSD1 KLHL38 KRTAP1-1 KRTAP10-1 KRTAP10-5 KRTAP12-4 KRTAP2-3 KRTAP4-11 KRTAP4-12 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE5A LNX1 MCRS1 MOBP NBPF19 NKD1 NOTCH2NLA NPDC1 NUFIP2 OTX1 P2RY6 PHLDA1 PIGS PRKAB2 PTPMT1 RHBDL1 RPS28 SDC3 SHFL SPATA3 SPRED2 TFAP2D TMEM190 TNP2 TRIM42 TTPA VASN VWC2 YY1 ZBTB24 ZDHHC1 ZIM2 ZNF165 ZNF264 ZNF440 ZNF491 ZNF524 ZNF564 ZNF575 ZNF578 ZNF581 ZNF587 ZNF672 ZNF764 ZNF786 ZNF792
Entrez ID		353133	85294
HPRD ID		13967	13936
Ensembl ID		ENSG00000197084	ENSG00000213417
Uniprot IDs		Q5T751	P0C7H8 Q9BYR9
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Negative Regulation Of Lens Fiber Cell Differentiation Identical Protein Binding Protein Binding Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Branch Elongation Of An Epithelium Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Axis Elongation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Elastic Fiber Negative Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Matrix Assembly Negative Regulation Of ERK1 And ERK2 Cascade Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Cellular Response To Growth Factor Stimulus Basement Membrane	Keratinization Epidermis Development Intermediate Filament Keratin Filament Tissue Development Protein Binding DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Hair Cycle
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