LCE1C and NTN4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCE1C	NTN4
Description		late cornified envelope 1C	netrin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Basement Membrane Plasma Membrane Laminin Complex
	Molecular Function	Protein Binding	Protein Binding Laminin-1 Binding
	Biological Process	Epidermis Development Keratinization	Axon Guidance Animal Organ Morphogenesis Tissue Development Neuron Remodeling Cell Migration Substrate Adhesion-dependent Cell Spreading Regulation Of Branching Involved In Salivary Gland Morphogenesis By Extracellular Matrix-epithelial Cell Signaling Basement Membrane Assembly
Pathways		Formation of the cornified envelope	Non-integrin membrane-ECM interactions Netrin-1 signaling
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Allergic dermatitis (nickel) ( 23921680) Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 23535729 23535733 29059683) Breast size ( 27182965) Diastolic blood pressure ( 30224653) Diffusing capacity of carbon monoxide ( 30694715) Refractive error ( 32231278)
Interacting Genes		75 interacting genes: ADAMTSL4 ALPP CHIC2 CHRD CRCT1 CREB5 CYSRT1 EFEMP1 EFEMP2 FBLN1 GUCD1 HOXA1 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE4A LCE5A MACO1 NECTIN2 NTAQ1 NTN4 NUTF2 ODF1 OIT3 OTX1 PLA2G10 PLAC8 PLSCR3 PLSCR4 POU4F2 PSMB1 SLC39A7 SPRED2 SPRY1 SPRY2 TGFB1 TRIM42 VASN VWC2 VWC2L	13 interacting genes: ADAMTSL4 CASK CYSRT1 HOXA1 KPRP KRTAP10-8 KRTAP21-2 KRTAP5-9 LCE1C MEOX2 NBPF19 NOTCH2NLA PLSCR1
Entrez ID		353133	59277
HPRD ID		13967	10121
Ensembl ID		ENSG00000197084	ENSG00000074527
Uniprot IDs		Q5T751	A8K3H6 B2RE43 Q9HB63
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Negative Regulation Of Lens Fiber Cell Differentiation Identical Protein Binding Protein Binding Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Branch Elongation Of An Epithelium Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Axis Elongation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Elastic Fiber Negative Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Matrix Assembly Negative Regulation Of ERK1 And ERK2 Cascade Bud Elongation Involved In Lung Branching Interstitial Matrix Regulation Of Cellular Response To Growth Factor Stimulus Basement Membrane	Epidermis Development Tissue Development Intermediate Filament Establishment Of Skin Barrier Skin Epidermis Development Semicircular Canal Formation Epithelium Development Pigment Cell Development
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