F7 and RCHY1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		F7	RCHY1
Description		coagulation factor VII	ring finger and CHY zinc finger domain containing 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Matrix Vesicle Serine-type Peptidase Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Chemotaxis Proteolysis Response To Stress Blood Coagulation Hemostasis Circadian Rhythm Response To Hormone Response To Carbon Dioxide Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Animal Organ Regeneration Response To Nutrient Levels Positive Regulation Of TOR Signaling Response To Estradiol Response To Vitamin K Response To Genistein Response To Estrogen Regulation Of Body Fluid Levels Positive Regulation Of Positive Chemotaxis Response To Growth Hormone Response To Cholesterol Response To Thyroid Hormone Response To Thyroxine Response To Thyroid Stimulating Hormone Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Astaxanthin Response To Thyrotropin-releasing Hormone	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Extrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		IIa Recombinant Human Coagulation Factor IX (Recombinant) (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Kappadione Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Factor VII ( 17903294) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Factor VII levels ( 20231535) Prothrombin time ( 22703881 29403010)	Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		7 interacting genes: ALB F10 F3 F9 GGCX HPN RCHY1	74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160
Entrez ID		2155	25898
HPRD ID		01965	07607
Ensembl ID		ENSG00000057593	ENSG00000163743
Uniprot IDs		B4DPM2 F5H8B0 P08709	Q96PM5
PDB IDs		1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF 4NA9 4NG9 4NGA 4X8S 4X8T 4X8U 4X8V 4YLQ 4YT6 4YT7 4Z6A 4ZMA 4ZXX 4ZXY 5I46 5L0S 5L2Y 5L2Z 5L30 5PA8 5PA9 5PAA 5PAB 5PAC 5PAE 5PAF 5PAG 5PAI 5PAJ 5PAK 5PAM 5PAN 5PAO 5PAQ 5PAR 5PAS 5PAT 5PAU 5PAV 5PAW 5PAX 5PAY 5PB0 5PB1 5PB2 5PB3 5PB4 5PB5 5PB6 5TQE 5TQF 5TQG 5U6J 8UUD	2JRJ 2K2C 2K2D 7YNX
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Serine-type Endopeptidase Activity Endoplasmic Reticulum Lumen Regulation Of Body Fluid Levels Protein Maturation Serine-type Peptidase Activity Proteolysis Protein Processing Regulation Of Biological Quality Protein Metabolic Process Activation Of Plasma Proteins Involved In Acute Inflammatory Response Gamma-glutamyl Carboxylase Activity Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Activation Of Blood Coagulation Via Clotting Cascade Positive Regulation Of TOR Signaling Serine-type Peptidase Complex Peptidase Activity Golgi Lumen Vitamin Binding Negative Regulation Of Bone Development Phospholipid Binding Negative Regulation Of Testosterone Biosynthetic Process Basement Membrane Disassembly Pilomotor Reflex Extracellular Space Regulation Of TOR Signaling Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid Hormone Generation Serine-type Exopeptidase Activity Error-free Translesion Synthesis Positive Regulation Of Epithelial Cell Proliferation Macromolecule Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion Positive Regulation Of Proteolysis Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Plasminogen Activation Regulation Of Bone Development Positive Regulation Of Hepatocyte Proliferation Toxic Substance Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Vitamin K Metabolic Process Extracellular Region Regulation Of Hepatocyte Proliferation Regulation Of Plasminogen Activation	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis
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