F7 and F9

Number of citations of the paper that reports this interaction (PubMedID 2248955)
0

Data Source:
HPRD (in vitro)

		F7	F9
Description		coagulation factor VII	coagulation factor IX
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Matrix Vesicle Serine-type Peptidase Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Chemotaxis Proteolysis Response To Stress Blood Coagulation Hemostasis Circadian Rhythm Response To Hormone Response To Carbon Dioxide Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Animal Organ Regeneration Response To Nutrient Levels Positive Regulation Of TOR Signaling Response To Estradiol Response To Vitamin K Response To Genistein Response To Estrogen Regulation Of Body Fluid Levels Positive Regulation Of Positive Chemotaxis Response To Growth Hormone Response To Cholesterol Response To Thyroid Hormone Response To Thyroxine Response To Thyroid Stimulating Hormone Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Astaxanthin Response To Thyrotropin-releasing Hormone	Proteolysis Blood Coagulation Hemostasis Zymogen Activation
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Extrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins	Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Protein hydroxylation Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX Defective F9 secretion Defective F9 activation Defective gamma-carboxylation of F9
Drugs		IIa Recombinant Human Coagulation Factor IX (Recombinant) (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Kappadione Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol	Antihemophilic factor, human recombinant Menadione TTP889 Turoctocog alfa Kappadione Coagulation factor VII human Antihemophilic factor human Emicizumab Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol
Diseases			Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Factor VII ( 17903294) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Factor VII levels ( 20231535) Prothrombin time ( 22703881 29403010)	Venous thromboembolism ( 31676865)
Interacting Genes		7 interacting genes: ALB F10 F3 F9 GGCX HPN RCHY1	5 interacting genes: F2 F7 F8 GGCX LRP1
Entrez ID		2155	2158
HPRD ID		01965	02385
Ensembl ID		ENSG00000057593	ENSG00000101981
Uniprot IDs		B4DPM2 F5H8B0 P08709	P00740
PDB IDs		1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF 4NA9 4NG9 4NGA 4X8S 4X8T 4X8U 4X8V 4YLQ 4YT6 4YT7 4Z6A 4ZMA 4ZXX 4ZXY 5I46 5L0S 5L2Y 5L2Z 5L30 5PA8 5PA9 5PAA 5PAB 5PAC 5PAE 5PAF 5PAG 5PAI 5PAJ 5PAK 5PAM 5PAN 5PAO 5PAQ 5PAR 5PAS 5PAT 5PAU 5PAV 5PAW 5PAX 5PAY 5PB0 5PB1 5PB2 5PB3 5PB4 5PB5 5PB6 5TQE 5TQF 5TQG 5U6J 8UUD	1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM 5F84 5F85 5F86 5JB8 5JB9 5JBA 5JBB 5JBC 5TNO 5TNT 5VYG 6MV4 6RFK 6X5J 6X5L 6X5P 7AHV 8EPC 8EPH 8EPK 8OL9 9BVK 9BVR
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Serine-type Endopeptidase Activity Endoplasmic Reticulum Lumen Regulation Of Body Fluid Levels Protein Maturation Serine-type Peptidase Activity Proteolysis Protein Processing Regulation Of Biological Quality Protein Metabolic Process Activation Of Plasma Proteins Involved In Acute Inflammatory Response Gamma-glutamyl Carboxylase Activity Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Activation Of Blood Coagulation Via Clotting Cascade Positive Regulation Of TOR Signaling Serine-type Peptidase Complex Peptidase Activity Golgi Lumen Vitamin Binding Negative Regulation Of Bone Development Phospholipid Binding Negative Regulation Of Testosterone Biosynthetic Process Basement Membrane Disassembly Pilomotor Reflex Extracellular Space Regulation Of TOR Signaling Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid Hormone Generation Serine-type Exopeptidase Activity Error-free Translesion Synthesis Positive Regulation Of Epithelial Cell Proliferation Macromolecule Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion Positive Regulation Of Proteolysis Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Plasminogen Activation Regulation Of Bone Development Positive Regulation Of Hepatocyte Proliferation Toxic Substance Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Vitamin K Metabolic Process Extracellular Region Regulation Of Hepatocyte Proliferation Regulation Of Plasminogen Activation	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Endoplasmic Reticulum Lumen Golgi Lumen Positive Regulation Of Blood Coagulation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Coagulation Acute-phase Response Protein Maturation Positive Regulation Of Wound Healing Acute Inflammatory Response Regulation Of Hemostasis Regulation Of Blood Coagulation Endopeptidase Activity Response To Astaxanthin Gamma-glutamyl Carboxylase Activity Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Calcium Ion Binding Serine-type Peptidase Activity Serine-type Peptidase Complex Response To Thyrotropin-releasing Hormone Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Regulation Of Wound Healing Serine-type Endopeptidase Activity Response To Carbon Dioxide Response To Thyroid Stimulating Hormone Negative Regulation Of Testosterone Biosynthetic Process Lipoprotein Particle Receptor Binding Regulation Of Response To Wounding Thrombospondin Receptor Activity Response To Genistein Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Neutrophil-mediated Killing Of Gram-negative Bacterium Response To Thyroxine Response To Vitamin K Response To Hydroxyisoflavone Positive Regulation Of Lysosomal Protein Catabolic Process Response To L-phenylalanine Derivative Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Response To Phenylpropanoid Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Testosterone Biosynthetic Process
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