F7 and F10

Number of citations of the paper that reports this interaction (PubMedID 11560488)
0

Data Source:
HPRD (in vitro)

		F7	F10
Description		coagulation factor VII	coagulation factor X
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Matrix Vesicle Serine-type Peptidase Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Phospholipid Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Chemotaxis Proteolysis Response To Stress Blood Coagulation Hemostasis Circadian Rhythm Response To Hormone Response To Carbon Dioxide Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Animal Organ Regeneration Response To Nutrient Levels Positive Regulation Of TOR Signaling Response To Estradiol Response To Vitamin K Response To Genistein Response To Estrogen Regulation Of Body Fluid Levels Positive Regulation Of Positive Chemotaxis Response To Growth Hormone Response To Cholesterol Response To Thyroid Hormone Response To Thyroxine Response To Thyroid Stimulating Hormone Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Astaxanthin Response To Thyrotropin-releasing Hormone	Proteolysis Blood Coagulation Hemostasis Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Extrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins	Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX
Drugs		IIa Recombinant Human Coagulation Factor IX (Recombinant) (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Kappadione Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol	Antihemophilic factor, human recombinant IIa Recombinant Human Coagulation Factor IX (Recombinant) Fondaparinux Heparin Enoxaparin gamma-carboxy-L-glutamic acid 4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE SSR-126517E LY-517717 Rivaroxaban Lanoteplase Idraparinux rNAPc2 Apixaban Otamixaban Eribaxaban (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE GW-813893 2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE 5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE 5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE 6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE 5-Chloro-N-{(3S)-1-[(2S)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1H-indole-2-sulfonamide 5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide 5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE 1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE 5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE 5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE 5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE 3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE 4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE 4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE 1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE Edoxaban Turoctocog alfa Protamine sulfate Bemiparin Kappadione Antithrombin Alfa Betrixaban Nafamostat Protein S human Coagulation factor VII human Anti-inhibitor coagulant complex Coagulation Factor IX Human Antihemophilic factor human Albutrepenonacog alfa Emicizumab Nonacog beta pegol Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Factor VII ( 17903294) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Factor VII levels ( 20231535) Prothrombin time ( 22703881 29403010)	Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Factor VII ( 17903294) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		7 interacting genes: ALB F10 F3 F9 GGCX HPN RCHY1	23 interacting genes: APOH CAMP F2 F3 F5 F7 F8 GAD2 GGCX H1-2 MGST3 NBPF19 NOTCH2NLA PLAT PLG PRKAB1 PROS1 SERPINA10 SERPINA5 SERPINB6 SERPINB8 TFPI UBQLN2
Entrez ID		2155	2159
HPRD ID		01965	01966
Ensembl ID		ENSG00000057593	ENSG00000126218
Uniprot IDs		B4DPM2 F5H8B0 P08709	P00742 Q5JVE7 Q5JVE8
PDB IDs		1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF 4NA9 4NG9 4NGA 4X8S 4X8T 4X8U 4X8V 4YLQ 4YT6 4YT7 4Z6A 4ZMA 4ZXX 4ZXY 5I46 5L0S 5L2Y 5L2Z 5L30 5PA8 5PA9 5PAA 5PAB 5PAC 5PAE 5PAF 5PAG 5PAI 5PAJ 5PAK 5PAM 5PAN 5PAO 5PAQ 5PAR 5PAS 5PAT 5PAU 5PAV 5PAW 5PAX 5PAY 5PB0 5PB1 5PB2 5PB3 5PB4 5PB5 5PB6 5TQE 5TQF 5TQG 5U6J 8UUD	1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1NFU 1NFW 1NFX 1NFY 1P0S 1V3X 1WU1 1XKA 1XKB 1Z6E 2BMG 2BOH 2BOK 2BQ6 2BQ7 2BQW 2CJI 2D1J 2EI6 2EI7 2EI8 2FZZ 2G00 2GD4 2H9E 2J2U 2J34 2J38 2J4I 2J94 2J95 2JKH 2P16 2P3F 2P3T 2P3U 2P93 2P94 2P95 2PHB 2PR3 2Q1J 2RA0 2UWL 2UWO 2UWP 2VH0 2VH6 2VVC 2VVU 2VVV 2VWL 2VWM 2VWN 2VWO 2W26 2W3I 2W3K 2WYG 2WYJ 2XBV 2XBW 2XBX 2XBY 2XC0 2XC4 2XC5 2Y5F 2Y5G 2Y5H 2Y7X 2Y7Z 2Y80 2Y81 2Y82 3CEN 3CS7 3ENS 3FFG 3HPT 3IIT 3K9X 3KL6 3KQB 3KQC 3KQD 3KQE 3LIW 3M36 3M37 3Q3K 3SW2 3TK5 3TK6 4A7I 4BTI 4BTT 4BTU 4Y6D 4Y71 4Y76 4Y79 4Y7A 4Y7B 4ZH8 4ZHA 5JQY 5JTC 5JZ8 5JZU 5K0H 5VOE 5VOF 6Q9F 6Q9I 6RK9 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7AHU 7BMI 7BMJ 7E6J 7TPP 7YB8 7YB9 7YBB 7YBC 8EOK 8RE5 8RE6 8RE7 8RE8 8RE9 9BVL 9CLI 9CM2 9CM9 9CTH
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Serine-type Endopeptidase Activity Endoplasmic Reticulum Lumen Regulation Of Body Fluid Levels Protein Maturation Serine-type Peptidase Activity Proteolysis Protein Processing Regulation Of Biological Quality Protein Metabolic Process Activation Of Plasma Proteins Involved In Acute Inflammatory Response Gamma-glutamyl Carboxylase Activity Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Activation Of Blood Coagulation Via Clotting Cascade Positive Regulation Of TOR Signaling Serine-type Peptidase Complex Peptidase Activity Golgi Lumen Vitamin Binding Negative Regulation Of Bone Development Phospholipid Binding Negative Regulation Of Testosterone Biosynthetic Process Basement Membrane Disassembly Pilomotor Reflex Extracellular Space Regulation Of TOR Signaling Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid Hormone Generation Serine-type Exopeptidase Activity Error-free Translesion Synthesis Positive Regulation Of Epithelial Cell Proliferation Macromolecule Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion Positive Regulation Of Proteolysis Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Plasminogen Activation Regulation Of Bone Development Positive Regulation Of Hepatocyte Proliferation Toxic Substance Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Vitamin K Metabolic Process Extracellular Region Regulation Of Hepatocyte Proliferation Regulation Of Plasminogen Activation	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Regulation Of Blood Coagulation Regulation Of Hemostasis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Response To Wounding Negative Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Extracellular Region Regulation Of Fibrinolysis Fibrinolysis Extracellular Matrix Serine-type Endopeptidase Inhibitor Activity Protein Maturation Peptidase Inhibitor Activity Serine-type Endopeptidase Activity Platelet Alpha Granule Lumen Serine-type Peptidase Complex Endoplasmic Reticulum Lumen Protein Processing Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Biological Quality Golgi Lumen Trans-synaptic Signaling By BDNF Protease Binding Biological Process Involved In Interaction With Symbiont Response To Vitamin K Serine Protease Inhibitor Complex Serine-type Peptidase Activity Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Blood Coagulation, Intrinsic Pathway Heparin Binding Plasminogen Activation Cytolysis By Host Of Symbiont Cells Trans-synaptic Signaling, Modulating Synaptic Transmission Extracellular Exosome Endopeptidase Activity Leukotriene Biosynthetic Process Platelet Alpha Granule Protein Activation Cascade Carboxylic Acid Biosynthetic Process
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