F7 and F3

Number of citations of the paper that reports this interaction (PMID 9925787)
17

Data Source:
HPRD (in vitro)

		F7	F3
Gene Name		coagulation factor VII (serum prothrombin conversion accelerator)	coagulation factor III (thromboplastin, tissue factor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Vesicle	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Matrix Intrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Serine-type Endopeptidase Activity Receptor Binding Calcium Ion Binding Protein Binding Serine-type Peptidase Activity	Protease Binding Cytokine Receptor Activity Protein Binding Phospholipid Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Proteolysis Blood Coagulation Blood Coagulation, Extrinsic Pathway Circadian Rhythm Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-glutamic Acid Carboxylation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Organ Regeneration Response To Vitamin K Response To Estrogen Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Response To Growth Hormone	Positive Regulation Of Endothelial Cell Proliferation Activation Of Plasma Proteins Involved In Acute Inflammatory Response Activation Of Blood Coagulation Via Clotting Cascade Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Blood Coagulation Blood Coagulation, Extrinsic Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling
Pathways		Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Post-translational protein modification Extrinsic Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation of protein precursors BMAL1:CLOCK,NPAS2 activates circadian gene expression Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Extrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Coagulation factor VIIa Coagulation Factor IX Menadione (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2\'-HYDROXY-3\'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3\'-NITRO-BIPHENYL-3-YL]-ACETIC ACID	Coagulation factor VIIa 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2\'-HYDROXY-3\'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3\'-NITRO-BIPHENYL-3-YL]-ACETIC ACID
Diseases
GWAS		Factor VII ( 17903294) Prothrombin time ( 22703881)	D-dimer levels ( 21502573) End-stage coagulation ( 23381943) Type 2 diabetes ( 22238593)
Protein-Protein Interactions		7 interactors: ALB F10 F3 F9 GGCX HPN RCHY1	5 interactors: F10 F7 FANCB FLNA PLG
Entrez ID		2155	2152
HPRD ID		01965	00603
Ensembl ID		ENSG00000057593	ENSG00000117525
Uniprot IDs		B4DPM2 P08709	P13726
PDB IDs		1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1NL8 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF	1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1NL8 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4
Enriched GO Terms of Interacting Partners?		Blood Coagulation, Extrinsic Pathway Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Blood Coagulation, Intrinsic Pathway Protein Activation Cascade Post-translational Protein Modification Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Activation Of Plasma Proteins Involved In Acute Inflammatory Response Proteolysis Regulation Of Protein Kinase B Signaling Maintenance Of Mitochondrion Location Activation Of Blood Coagulation Via Clotting Cascade Basement Membrane Disassembly Positive Regulation Of Behavior Positive Regulation Of Epithelial Cell Proliferation Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress Pilomotor Reflex Regulation Of Behavior Positive Regulation Of Plasminogen Activation Positive Regulation Of Hepatocyte Proliferation Regulation Of Thyroid Hormone Generation Peptidyl-amino Acid Modification Negative Regulation Of Alkaline Phosphatase Activity Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation By Host Of Viral Transcription Regulation Of Epithelial Cell Proliferation Positive Regulation Of Proteolysis Regulation Of Hepatocyte Proliferation Sodium-independent Organic Anion Transport Positive Regulation Of Cell Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Cell Motility Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Response To Thyroid Hormone Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Establishment Of Epithelial Cell Polarity Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm	Blood Coagulation, Extrinsic Pathway Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Peptidyl-glutamic Acid Carboxylation Response To Wounding Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Response To Stress Platelet Degranulation Positive Regulation Of Protein Kinase B Signaling Regulation Of Blood Coagulation Regulation Of Protein Kinase B Signaling Regulation Of Wound Healing Positive Regulation Of Intracellular Signal Transduction Protein Activation Cascade Response To Vitamin K Mononuclear Cell Migration Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Platelet Activation Post-translational Protein Modification Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Cellular Component Movement Negative Regulation Of Fibrinolysis Positive Regulation Of Locomotion Proteolysis MRNA Transcription From RNA Polymerase II Promoter Regulation Of Fibrinolysis MRNA Transcription Blood Coagulation, Intrinsic Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Localization To Cell Surface Mitotic Spindle Assembly Early Endosome To Late Endosome Transport Trophoblast Giant Cell Differentiation Secretion By Cell Actin Crosslink Formation Response To Stimulus Cytoplasmic Sequestering Of Protein Labyrinthine Layer Blood Vessel Development Muscle Cell Cellular Homeostasis
Tagcloud ?		4e autoregulation betatc6 biosynthesis cap dependently dephosphorylation exert exogenous glucose immunosuppressant incubation insulin interacting islet islets latter mediate phas phosphatidylinositol phosphodiesterase rapamycin secreted serve stimulate stimulates theophylline translation wortmannin	ag ba construct csf defective efficiently equivalence g gcsfr granulocyte granulopoiesis kinetics neutropenia nonsaturating r retain saturating scn stat1 stat3 stat5 transactivation transfectants triangle truncated tyrosines up715 y704 y744
Tagcloud (Difference) ?		4e autoregulation betatc6 biosynthesis cap dependently dephosphorylation exert exogenous glucose immunosuppressant incubation insulin interacting islet islets latter mediate phas phosphatidylinositol phosphodiesterase rapamycin secreted serve stimulate stimulates theophylline translation wortmannin	ag ba construct csf defective efficiently equivalence g gcsfr granulocyte granulopoiesis kinetics neutropenia nonsaturating r retain saturating scn stat1 stat3 stat5 transactivation transfectants triangle truncated tyrosines up715 y704 y744
Tagcloud (Intersection) ?