F7 and GGCX

Number of citations of the paper that reports this interaction (PMID 8647260)
7

Data Source:
HPRD (in vitro)

		F7	GGCX
Gene Name		coagulation factor VII (serum prothrombin conversion accelerator)	gamma-glutamyl carboxylase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Vesicle	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Glycoprotein Binding Serine-type Endopeptidase Activity Receptor Binding Calcium Ion Binding Protein Binding Serine-type Peptidase Activity	Gamma-glutamyl Carboxylase Activity
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Proteolysis Blood Coagulation Blood Coagulation, Extrinsic Pathway Circadian Rhythm Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-glutamic Acid Carboxylation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Organ Regeneration Response To Vitamin K Response To Estrogen Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Response To Growth Hormone	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Post-translational protein modification Extrinsic Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation of protein precursors BMAL1:CLOCK,NPAS2 activates circadian gene expression Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation of protein precursors Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Coagulation factor VIIa Coagulation Factor IX Menadione (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2\'-HYDROXY-3\'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3\'-NITRO-BIPHENYL-3-YL]-ACETIC ACID	Coagulation factor VIIa Drotrecogin alfa Coagulation Factor IX L-Glutamic Acid Menadione Phytonadione Anisindione
Diseases
GWAS		Factor VII ( 17903294) Prothrombin time ( 22703881)	Prostate cancer ( 21743467)
Protein-Protein Interactions		7 interactors: ALB F10 F3 F9 GGCX HPN RCHY1	6 interactors: BGLAP F10 F2 F7 F9 PROC
Entrez ID		2155	2677
HPRD ID		01965	00665
Ensembl ID		ENSG00000057593	ENSG00000115486
Uniprot IDs		B4DPM2 P08709	P38435
PDB IDs		1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1NL8 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF
Enriched GO Terms of Interacting Partners?		Blood Coagulation, Extrinsic Pathway Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Blood Coagulation, Intrinsic Pathway Protein Activation Cascade Post-translational Protein Modification Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Activation Of Plasma Proteins Involved In Acute Inflammatory Response Proteolysis Regulation Of Protein Kinase B Signaling Maintenance Of Mitochondrion Location Activation Of Blood Coagulation Via Clotting Cascade Basement Membrane Disassembly Positive Regulation Of Behavior Positive Regulation Of Epithelial Cell Proliferation Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress Pilomotor Reflex Regulation Of Behavior Positive Regulation Of Plasminogen Activation Positive Regulation Of Hepatocyte Proliferation Regulation Of Thyroid Hormone Generation Peptidyl-amino Acid Modification Negative Regulation Of Alkaline Phosphatase Activity Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation By Host Of Viral Transcription Regulation Of Epithelial Cell Proliferation Positive Regulation Of Proteolysis Regulation Of Hepatocyte Proliferation Sodium-independent Organic Anion Transport Positive Regulation Of Cell Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Cell Motility Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Response To Thyroid Hormone Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Establishment Of Epithelial Cell Polarity Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm	Peptidyl-glutamic Acid Carboxylation Blood Coagulation, Extrinsic Pathway Post-translational Protein Modification Blood Coagulation, Intrinsic Pathway Blood Coagulation Hemostasis Protein Activation Cascade Regulation Of Body Fluid Levels Wound Healing Response To Wounding Response To Vitamin K Peptidyl-amino Acid Modification Regulation Of Blood Coagulation Regulation Of Wound Healing Proteolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Positive Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Positive Regulation Of Protein Kinase B Signaling Cellular Protein Modification Process Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Response To Vitamin Response To Stress Regulation Of Protein Kinase B Signaling Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cellular Protein Metabolic Process Response To Estrogen Response To Nutrient Leukocyte Migration Response To Stimulus Response To Hydroxyisoflavone Negative Regulation Of Fibrinolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Protein Metabolic Process Regulation Of Fibrinolysis Negative Regulation Of Astrocyte Differentiation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Gravity Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Vitamin D Response To Nutrient Levels
Tagcloud ?		4e autoregulation betatc6 biosynthesis cap dependently dephosphorylation exert exogenous glucose immunosuppressant incubation insulin interacting islet islets latter mediate phas phosphatidylinositol phosphodiesterase rapamycin secreted serve stimulate stimulates theophylline translation wortmannin
Tagcloud (Difference) ?		4e autoregulation betatc6 biosynthesis cap dependently dephosphorylation exert exogenous glucose immunosuppressant incubation insulin interacting islet islets latter mediate phas phosphatidylinositol phosphodiesterase rapamycin secreted serve stimulate stimulates theophylline translation wortmannin
Tagcloud (Intersection) ?