EPO and S100A6

Number of citations of the paper that reports this interaction (PubMedID 35053268)
88

Data Source:
BioGRID (pull down)

		EPO	S100A6
Description		erythropoietin	S100 calcium binding protein A6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Cell Body	Ruffle Extracellular Region Nucleus Nuclear Envelope Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extracellular Matrix Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Cytokine Activity Erythropoietin Receptor Binding Hormone Activity Protein Binding Protein Kinase Activator Activity	Calcium Ion Binding Protein Binding Tropomyosin Binding Zinc Ion Binding Monoatomic Ion Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Apoptotic Process Response To Stress Acute-phase Response Signal Transduction Embryo Implantation Response To Nutrient Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Salt Stress Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Neuron Projection Development Erythrocyte Differentiation Response To Lipopolysaccharide Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Response To Vitamin A Response To Testosterone Erythropoietin-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Hemoglobin Biosynthetic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Response To Estrogen Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Response To Axon Injury Response To Electrical Stimulus Response To Hyperoxia Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Hyperosmotic Response Response To Dexamethasone Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Erythrocyte Apoptotic Process	Signal Transduction Axonogenesis Monoatomic Ion Transmembrane Transport Positive Regulation Of Fibroblast Proliferation
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Blood protein levels ( 30072576) Hematocrit ( 24777453 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 24777453 32327693) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Other erythrocyte phenotypes ( 19862010) Plateletcrit ( 32888494) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		7 interacting genes: CFTR EP300 EPOR HIF1A S100A2 S100A6 S100P	50 interacting genes: ANXA11 ANXA2 CACYBP CEP20 CEP43 CLCF1 CNTF CSF2 CSF3 CTF1 EBI3 EPO FAM25A FAM25C FAM25G FKBP4 FLT3LG GAPDH GH1 GH2 IFNB1 IFNW1 IL10 IL11 IL12A IL13 IL15 IL19 IL2 IL20 IL21 IL22 IL24 IL26 IL27 IL3 IL31 IL5 IL9 KITLG LEP MDM2 OFD1 PEX5 PPID PRL S100B SUGT1 THPO TP53
Entrez ID		2056	6277
HPRD ID		00586	00237
Ensembl ID		ENSG00000130427	ENSG00000197956
Uniprot IDs		G9JKG7 P01588	P06703
PDB IDs		1BUY 1CN4 1EER	1K8U 1K96 1K9K 1K9P 2M1K 4YBH
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding Transition Metal Ion Binding Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport P53 Binding Regulation Of ATP Metabolic Process Peptidyl-lysine Propionylation Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Nuclear Receptor Binding Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcription Coactivator Binding Erythropoietin Receptor Activity Positive Regulation Of Protein Localization Positive Regulation Of Insulin Secretion Regulation Of Protein Transport TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Endothelial Cell Migration Positive Regulation Of Anion Channel Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Regulation Of Cellular Localization Positive Regulation Of Peptide Hormone Secretion Animal Organ Morphogenesis Positive Regulation Of Peptide Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Monoatomic Anion Transport N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Regulation Of Generation Of Precursor Metabolites And Energy Peptide Lactyltransferase (CoA-dependent) Activity Neural Fold Elevation Formation	Cytokine Activity Extracellular Space Cytokine-mediated Signaling Pathway Extracellular Region Growth Factor Activity Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Differentiation Cell Activation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Immune System Process Leukocyte Activation Cytokine Receptor Binding Regulation Of Multicellular Organismal Process Lymphocyte Activation Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Immune Response Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Cell Activation Lymphocyte Differentiation Mononuclear Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Activation Positive Regulation Of Developmental Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Lymphocyte Proliferation Positive Regulation Of Cytokine Production Regulation Of Developmental Process Mononuclear Cell Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Leukocyte Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of T Cell Activation T Cell Activation
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