EPO

Gene Name		erythropoietin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface
	Molecular Function	Erythropoietin Receptor Binding Hormone Activity Protein Binding Protein Kinase Activator Activity
	Biological Process	Apoptotic Process Signal Transduction Embryo Implantation Aging Blood Circulation Positive Regulation Of Cell Proliferation Response To Salt Stress Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Vitamin A Response To Testosterone Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Hemoglobin Biosynthetic Process Erythrocyte Maturation Response To Estrogen Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Response To Axon Injury Response To Electrical Stimulus Response To Hyperoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Interleukin-1 Cellular Response To Hypoxia Cellular Hyperosmotic Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Erythrocyte Apoptotic Process Negative Regulation Of Cation Channel Activity
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Other erythrocyte phenotypes ( 19862010)
Protein-protein Interactions		2 interactors: EP300 EPOR
Entrez ID		2056
HPRD ID		00586
Ensembl ID		ENSG00000130427
Uniprot IDs		B7ZKK5 G9JKG7 P01588
PDB IDs		1BUY 1CN4 1EER
Enriched GO Terms of Interacting Partners?		Histone H2B Acetylation Erythropoietin-mediated Signaling Pathway N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Cellular Response To Erythropoietin Regulation Of Tubulin Deacetylation Heart Development Positive Regulation By Host Of Viral Transcription N-terminal Protein Amino Acid Acetylation Cardiovascular System Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Decidualization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Interaction With Symbiont Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Maternal Placenta Development Positive Regulation Of Viral Transcription Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Deacetylation Histone H4 Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Tissue Development Cellular Response To Heat Positive Regulation Of Protein Binding Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Organic Substance Positive Regulation Of Type I Interferon Production Maternal Process Involved In Female Pregnancy Somitogenesis Protein Stabilization Endoplasmic Reticulum Unfolded Protein Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels ER-nucleus Signaling Pathway Regulation Of Type I Interferon Production Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Response To Heat Nervous System Development Histone Acetylation Signal Transduction By P53 Class Mediator
Tagcloud ?		actual agonist angstrom antagonist apart configuration crystal dimer efficiency epor erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded