EPO

Description		erythropoietin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Cell Body
	Molecular Function	Cytokine Activity Erythropoietin Receptor Binding Hormone Activity Protein Binding Protein Kinase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Apoptotic Process Response To Stress Acute-phase Response Signal Transduction Embryo Implantation Response To Nutrient Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Salt Stress Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Neuron Projection Development Erythrocyte Differentiation Response To Lipopolysaccharide Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Response To Vitamin A Response To Testosterone Erythropoietin-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Hemoglobin Biosynthetic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Response To Estrogen Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Response To Axon Injury Response To Electrical Stimulus Response To Hyperoxia Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Hyperosmotic Response Response To Dexamethasone Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Erythrocyte Apoptotic Process
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Hematocrit ( 24777453 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 24777453 32327693) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Other erythrocyte phenotypes ( 19862010) Plateletcrit ( 32888494) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: CFTR EP300 EPOR HIF1A S100A2 S100A6 S100P
Entrez ID		2056
HPRD ID		00586
Ensembl ID		ENSG00000130427
Uniprot IDs		G9JKG7 P01588
PDB IDs		1BUY 1CN4 1EER
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding Transition Metal Ion Binding Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport P53 Binding Regulation Of ATP Metabolic Process Peptidyl-lysine Propionylation Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Nuclear Receptor Binding Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcription Coactivator Binding Erythropoietin Receptor Activity Positive Regulation Of Protein Localization Positive Regulation Of Insulin Secretion Regulation Of Protein Transport TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Endothelial Cell Migration Positive Regulation Of Anion Channel Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Regulation Of Cellular Localization Positive Regulation Of Peptide Hormone Secretion Animal Organ Morphogenesis Positive Regulation Of Peptide Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Monoatomic Anion Transport N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Regulation Of Generation Of Precursor Metabolites And Energy Peptide Lactyltransferase (CoA-dependent) Activity Neural Fold Elevation Formation
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