EPO and S100A2

Number of citations of the paper that reports this interaction (PubMedID 35053268)
88

Data Source:
BioGRID (pull down)

		EPO	S100A2
Description		erythropoietin	S100 calcium binding protein A2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Cell Body
	Molecular Function	Cytokine Activity Erythropoietin Receptor Binding Hormone Activity Protein Binding Protein Kinase Activator Activity	Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Transition Metal Ion Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Apoptotic Process Response To Stress Acute-phase Response Signal Transduction Embryo Implantation Response To Nutrient Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Salt Stress Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Neuron Projection Development Erythrocyte Differentiation Response To Lipopolysaccharide Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Response To Vitamin A Response To Testosterone Erythropoietin-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Hemoglobin Biosynthetic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Response To Estrogen Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Response To Axon Injury Response To Electrical Stimulus Response To Hyperoxia Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Hyperosmotic Response Response To Dexamethasone Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Erythrocyte Apoptotic Process	Endothelial Cell Migration
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Olopatadine Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576) Hematocrit ( 24777453 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 24777453 32327693) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Other erythrocyte phenotypes ( 19862010) Plateletcrit ( 32888494) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: CFTR EP300 EPOR HIF1A S100A2 S100A6 S100P	16 interacting genes: ARL13B CEP20 EPO FAM209A FKBP4 MDM2 PPID S100A1 S100A3 S100B S100P STUB1 TP53 TPM1 TPM2 TPM3
Entrez ID		2056	6273
HPRD ID		00586	01508
Ensembl ID		ENSG00000130427	ENSG00000196754
Uniprot IDs		G9JKG7 P01588	P29034 Q5RHS7 R4GN49
PDB IDs		1BUY 1CN4 1EER	2RGI 4DUQ
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding Transition Metal Ion Binding Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport P53 Binding Regulation Of ATP Metabolic Process Peptidyl-lysine Propionylation Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Nuclear Receptor Binding Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcription Coactivator Binding Erythropoietin Receptor Activity Positive Regulation Of Protein Localization Positive Regulation Of Insulin Secretion Regulation Of Protein Transport TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Endothelial Cell Migration Positive Regulation Of Anion Channel Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Regulation Of Cellular Localization Positive Regulation Of Peptide Hormone Secretion Animal Organ Morphogenesis Positive Regulation Of Peptide Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Monoatomic Anion Transport N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Regulation Of Generation Of Precursor Metabolites And Energy Peptide Lactyltransferase (CoA-dependent) Activity Neural Fold Elevation Formation	Muscle Thin Filament Tropomyosin Calcium-dependent Protein Binding Cellular Response To Actinomycin D Response To Hypoxia Response To Decreased Oxygen Levels Tau Protein Binding Response To Actinomycin D Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Cellular Response To UV-C Response To Oxygen Levels Cellular Response To Oxygen Levels Heat Shock Protein Binding Protein Homodimerization Activity Cellular Response To Antibiotic Regulation Of Blood Circulation Cellular Response To UV Response To UV-C Identical Protein Binding S100 Protein Binding Actin Filament Regulation Of System Process Response To Salt Stress Cellular Response To Light Stimulus Transition Metal Ion Binding Cytoplasm System Process Cytoskeleton Disordered Domain Specific Binding Cellular Response To Gamma Radiation Response To UV Cytosol Regulation Of ATP-dependent Activity Peptidyl-prolyl Cis-trans Isomerase Activity Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Embryo Implantation Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Erythrocyte Apoptotic Process Steroid Hormone Receptor Complex Assembly Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Heart Contraction DNA Damage Response, Signal Transduction By P53 Class Mediator Supramolecular Fiber Organization Hsp90 Protein Binding Hsp70 Protein Binding Regulation Of Mitophagy
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