EPO and EPOR

Number of citations of the paper that reports this interaction (PMID 9808045)
29

Data Source:
HPRD (in vivo)

		EPO	EPOR
Gene Name		erythropoietin	erythropoietin receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface	Extracellular Region Integral Component Of Plasma Membrane
	Molecular Function	Erythropoietin Receptor Binding Hormone Activity Protein Binding Protein Kinase Activator Activity	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Embryo Implantation Aging Blood Circulation Positive Regulation Of Cell Proliferation Response To Salt Stress Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Vitamin A Response To Testosterone Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Hemoglobin Biosynthetic Process Erythrocyte Maturation Response To Estrogen Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ras Protein Signal Transduction Response To Axon Injury Response To Electrical Stimulus Response To Hyperoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Interleukin-1 Cellular Response To Hypoxia Cellular Hyperosmotic Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Erythrocyte Apoptotic Process Negative Regulation Of Cation Channel Activity	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Decidualization
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Regulation of gene expression by Hypoxia-inducible Factor
Drugs			Darbepoetin alfa Epoetin alfa 3,5 DIBROMOTYROSINE Peginesatide
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Other erythrocyte phenotypes ( 19862010)
Protein-Protein Interactions		2 interactors: EP300 EPOR	36 interactors: ATXN2L CBL CISH CRKL CSF2RB EPO GAB1 GAB2 GNAI1 GNB2L1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK SYP VAV1
Entrez ID		2056	2057
HPRD ID		00586	00587
Ensembl ID		ENSG00000130427	ENSG00000187266
Uniprot IDs		B7ZKK5 G9JKG7 P01588	P19235
PDB IDs		1BUY 1CN4 1EER	1CN4 1EBA 1EBP 1EER 1ERN 2JIX
Enriched GO Terms of Interacting Partners?		Histone H2B Acetylation Erythropoietin-mediated Signaling Pathway N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Cellular Response To Erythropoietin Regulation Of Tubulin Deacetylation Heart Development Positive Regulation By Host Of Viral Transcription N-terminal Protein Amino Acid Acetylation Cardiovascular System Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Decidualization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Interaction With Symbiont Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Maternal Placenta Development Positive Regulation Of Viral Transcription Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Deacetylation Histone H4 Acetylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Tissue Development Cellular Response To Heat Positive Regulation Of Protein Binding Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Organic Substance Positive Regulation Of Type I Interferon Production Maternal Process Involved In Female Pregnancy Somitogenesis Protein Stabilization Endoplasmic Reticulum Unfolded Protein Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels ER-nucleus Signaling Pathway Regulation Of Type I Interferon Production Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Response To Heat Nervous System Development Histone Acetylation Signal Transduction By P53 Class Mediator	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Hormone Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Response To Organic Substance Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Intracellular Signal Transduction Cellular Response To Peptide Regulation Of Kinase Activity Fc Receptor Signaling Pathway Response To Peptide Hormone Regulation Of Body Fluid Levels JAK-STAT Cascade Response To Peptide Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Blood Coagulation Regulation Of Immune System Process Hemostasis Innate Immune Response Defense Response Cellular Response To Hormone Stimulus Cellular Response To Organonitrogen Compound Regulation Of Signaling Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Protein Kinase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Wounding Wound Healing Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Signaling Cell Communication
Tagcloud ?		actual agonist angstrom antagonist apart configuration crystal dimer efficiency epor erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded	actual agonist angstrom antagonist apart configuration crystal dimer efficiency erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		actual agonist angstrom antagonist apart configuration crystal dimer efficiency epor erythropoietin far formed hematopoietic homodimerization insights interact ligands mimetic organization peptide permit plasticity preformed recognition resolution spanning thought unliganded