EPO and EPOR

Number of citations of the paper that reports this interaction (PubMedID 10318834)
0

Data Source:
HPRD (in vivo)

		EPO	EPOR
Description		erythropoietin	erythropoietin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Cell Body	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Cytokine Activity Erythropoietin Receptor Binding Hormone Activity Protein Binding Protein Kinase Activator Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Apoptotic Process Response To Stress Acute-phase Response Signal Transduction Embryo Implantation Response To Nutrient Blood Circulation Positive Regulation Of Cell Population Proliferation Response To Salt Stress Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Neuron Projection Development Erythrocyte Differentiation Response To Lipopolysaccharide Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Response To Vitamin A Response To Testosterone Erythropoietin-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Hemoglobin Biosynthetic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Erythrocyte Maturation Response To Estrogen Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Response To Axon Injury Response To Electrical Stimulus Response To Hyperoxia Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Hyperosmotic Response Response To Dexamethasone Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Erythrocyte Apoptotic Process	Signal Transduction Brain Development Heart Development Erythropoietin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Decidualization
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	Signaling by Erythropoietin Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases			Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Blood protein levels ( 30072576) Hematocrit ( 24777453 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 24777453 32327693) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Other erythrocyte phenotypes ( 19862010) Plateletcrit ( 32888494) Pursuit maintenance gain in psychotic disorders ( 29064472) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)	Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)
Interacting Genes		7 interacting genes: CFTR EP300 EPOR HIF1A S100A2 S100A6 S100P	42 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 RNF128 RNF43 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL ZNRF3
Entrez ID		2056	2057
HPRD ID		00586	00587
Ensembl ID		ENSG00000130427	ENSG00000187266
Uniprot IDs		G9JKG7 P01588	P19235
PDB IDs		1BUY 1CN4 1EER	1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6I4X 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL 8VUI 8VVM 8VVO
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Binding Transition Metal Ion Binding Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport P53 Binding Regulation Of ATP Metabolic Process Peptidyl-lysine Propionylation Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Nuclear Receptor Binding Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcription Coactivator Binding Erythropoietin Receptor Activity Positive Regulation Of Protein Localization Positive Regulation Of Insulin Secretion Regulation Of Protein Transport TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Endothelial Cell Migration Positive Regulation Of Anion Channel Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Regulation Of Cellular Localization Positive Regulation Of Peptide Hormone Secretion Animal Organ Morphogenesis Positive Regulation Of Peptide Secretion Regulation Of Establishment Of Protein Localization Positive Regulation Of Monoatomic Anion Transport N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Regulation Of Generation Of Precursor Metabolites And Energy Peptide Lactyltransferase (CoA-dependent) Activity Neural Fold Elevation Formation	Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytokine-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Proliferation Immune Effector Process Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Immune System Process Regulation Of Immune Response Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Regulation Of Cell Communication Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Defense Response Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Activation Erythropoietin-mediated Signaling Pathway Natural Killer Cell Mediated Immunity Regulation Of Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Phosphorylation-dependent Protein Binding Regulation Of Mononuclear Cell Proliferation Myeloid Cell Differentiation Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Positive Regulation Of Cell Migration B Cell Receptor Signaling Pathway Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Motility Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Locomotion Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Cytosol Positive Regulation Of Mast Cell Proliferation
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