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ENG and ACVR2A
Number of citations of the paper that reports this interaction (PubMedID
9872992
)
0
Data Source:
HPRD
(in vivo)
ENG
ACVR2A
Description
endoglin
activin A receptor type 2A
Image
GO Annotations
Cellular Component
Extracellular Space
Plasma Membrane
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Nuclear Body
Receptor Complex
Endothelial Microparticle
Cytoplasm
Plasma Membrane
Cell Surface
Membrane
Inhibin-betaglycan-ActRII Complex
Receptor Complex
Activin Receptor Complex
Molecular Function
Transmembrane Signaling Receptor Activity
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
Galactose Binding
Glycosaminoglycan Binding
Coreceptor Activity
Signaling Receptor Activator Activity
Type I Transforming Growth Factor Beta Receptor Binding
BMP Binding
Identical Protein Binding
Protein Homodimerization Activity
Activin Binding
Transforming Growth Factor Beta Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Coreceptor Activity
Kinase Activity
Activin Receptor Activity, Type I
Activin Receptor Activity, Type II
Transferase Activity
Activin Receptor Activity
Growth Factor Binding
PDZ Domain Binding
Inhibin Binding
Identical Protein Binding
Metal Ion Binding
Activin Binding
BMP Receptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Heart Looping
Sprouting Angiogenesis
Positive Regulation Of Systemic Arterial Blood Pressure
Outflow Tract Septum Morphogenesis
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Endocardial Cushion Morphogenesis
Cardiac Ventricle Morphogenesis
Cardiac Atrium Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Cell Migration Involved In Endocardial Cushion Formation
Regulation Of DNA-templated Transcription
Cell Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Heart Development
Negative Regulation Of Gene Expression
Regulation Of Cardiac Muscle Cell Apoptotic Process
Cell Migration
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Central Nervous System Vasculogenesis
Extracellular Matrix Disassembly
Regulation Of Cell Adhesion
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Dorsal Aorta Morphogenesis
Wound Healing
Regulation Of Cell Population Proliferation
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Smooth Muscle Tissue Development
Artery Morphogenesis
Venous Blood Vessel Morphogenesis
Cell Motility
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Atrial Cardiac Muscle Tissue Morphogenesis
Cell Chemotaxis
Positive Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of SMAD Protein Signal Transduction
Detection Of Hypoxia
Endocardial Cushion To Mesenchymal Transition
Vascular Associated Smooth Muscle Cell Development
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Atrioventricular Canal Morphogenesis
Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Osteoblast Differentiation
Gastrulation With Mouth Forming Second
Positive Regulation Of Protein Phosphorylation
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Spermatogenesis
Determination Of Left/right Symmetry
Pattern Specification Process
Mesoderm Development
Male Gonad Development
Anterior/posterior Pattern Specification
Regulation Of Signal Transduction
Negative Regulation Of Ossification
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Developmental Process
Activin Receptor Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Odontogenesis Of Dentin-containing Tooth
Sperm Ejaculation
Penile Erection
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Skeletal System Development
Sertoli Cell Proliferation
Positive Regulation Of SMAD Protein Signal Transduction
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Pathways
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TGFBR3 regulates activin signaling
Drugs
Carotuximab
Sotatercept
Diseases
Hereditary hemorrhagic telangiectasia (HHT)
GWAS
Blood protein levels (
30072576
)
Body mass index (
26426971
)
Metabolic syndrome (
20694148
)
Monocyte count (
32888494
)
Adult body size (
32376654
)
Adventurousness (
30643258
)
Arterial stiffness index (
31235810
)
Asthma (adult onset) (
31036433
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
)
Cerebrospinal T-tau levels (
28247064
)
Diastolic blood pressure (
30224653
)
Eosinophil count (
32888494
)
Estimated glomerular filtration rate (
31015462
)
Feeling hurt (
29500382
)
Feeling miserable (
29500382
)
Feeling nervous (
29500382
)
Feeling tense (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Glomerular filtration rate (creatinine) (
26831199
)
Haemorrhoidal disease (
33888516
)
HDL cholesterol levels (
32203549
)
High myopia (
31816047
)
Loneliness (MTAG) (
29970889
)
Neutrophil percentage of granulocytes (
27863252
)
Photic sneeze reflex (
30899065
)
Refractive error (
32231278
)
Response to statin therapy (
20339536
)
Retinal detachment or retinal break (
31816047
)
Urate levels (
31985003
23263486
)
White blood cell count (basophil) (
27863252
)
Interacting Genes
13 interacting genes:
ACVR1
ACVR2A
BMP2
BMP7
DYNLT4
GDF2
INHBA
TGFB1
TGFB2
TGFB3
TGFBR1
TGFBR2
TGFBR3
23 interacting genes:
ACVRL1
BMP10
BMP2
BMP4
BMP6
BMP7
CRIPTO
DAXX
DYNLT4
ENG
ERBIN
GDF2
GDF5
GDF9
IGSF1
INHBA
INHBB
INHBC
MAGI2
NODAL
PRSS50
SYNJ2BP
TGFBR3
Entrez ID
2022
92
HPRD ID
00565
00025
Ensembl ID
ENSG00000106991
ENSG00000121989
Uniprot IDs
B7Z6Y5
F5GX88
P17813
Q5T9B9
Q96CG0
P27037
PDB IDs
5HZV
5HZW
5I04
3Q4T
3SOC
4ASX
5NH3
7U5P
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition
Response To Growth Factor
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Epithelial To Mesenchymal Transition
Animal Organ Development
Type II Transforming Growth Factor Beta Receptor Binding
Activin Receptor Signaling Pathway
Activin Binding
Type III Transforming Growth Factor Beta Receptor Binding
Epithelial To Mesenchymal Transition
Odontogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Mesenchymal Cell Differentiation
Animal Organ Morphogenesis
Transforming Growth Factor Beta Binding
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Intracellular Signal Transduction
Activin Receptor Complex
Activin Receptor Activity, Type I
Positive Regulation Of Cell Differentiation
Tissue Morphogenesis
Heart Development
Cardiac Septum Morphogenesis
Gland Morphogenesis
Growth Factor Activity
Cellular Response To BMP Stimulus
Positive Regulation Of Developmental Process
Roof Of Mouth Development
Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition
BMP Signaling Pathway
Tube Morphogenesis
Salivary Gland Morphogenesis
Regulation Of Multicellular Organismal Development
Anatomical Structure Morphogenesis
Ventricular Septum Morphogenesis
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Secondary Palate Development
Regulation Of Cell Differentiation
Cytokine Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of SMAD Protein Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Regulation Of SMAD Protein Signal Transduction
Growth Factor Activity
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
BMP Signaling Pathway
Cytokine Activity
Activin Receptor Signaling Pathway
Positive Regulation Of Cartilage Development
Cell Surface Receptor Signaling Pathway
Cellular Response To BMP Stimulus
Regulation Of Cartilage Development
Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Heart Development
Extracellular Space
Cellular Response To Growth Factor Stimulus
Signal Transduction
Response To Growth Factor
Positive Regulation Of Epithelial Cell Differentiation
Regulation Of Intracellular Signal Transduction
Cardiac Epithelial To Mesenchymal Transition
Negative Regulation Of Cell Migration
Negative Regulation Of Cell Motility
Animal Organ Development
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Development
Negative Regulation Of Locomotion
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Regulation Of Signal Transduction
Regulation Of Cell Migration
Epithelial To Mesenchymal Transition
Regulation Of Epithelial Cell Differentiation
BMP Receptor Binding
Positive Regulation Of BMP Signaling Pathway
Tissue Morphogenesis
Enzyme Activator Complex
Regulation Of Cell Motility
Positive Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Differentiation
Regulation Of Locomotion
Transforming Growth Factor Beta Receptor Signaling Pathway
Cartilage Development
Mesenchymal Cell Differentiation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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