ENG and TCTEX1D4

Number of citations of the paper that reports this interaction (PMID 16982625)
11

Data Source:
HPRD (in vivo, two hybrid)

		ENG	TCTEX1D4
Gene Name		endoglin	Tctex1 domain containing 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Focal Adhesion External Side Of Plasma Membrane Cell Surface Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex Endothelial Microparticle	Acrosomal Vesicle Nucleus Microtubule Organizing Center Axoneme Sperm Flagellum
	Molecular Function	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chronological Cell Aging Patterning Of Blood Vessels Vasculogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Systemic Arterial Blood Pressure Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Extracellular Matrix Disassembly Regulation Of Cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Autophosphorylation Response To Corticosteroid Positive Regulation Of Collagen Biosynthetic Process Intracellular Signal Transduction Response To Statin Wound Healing Regulation Of Cell Proliferation Regulation Of Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Cell Motility Negative Regulation Of Nitric-oxide Synthase Activity Cell Chemotaxis Bone Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Constituent Secretion Detection Of Hypoxia Cellular Response To Mechanical Stimulus Response To Transforming Growth Factor Beta
Pathways
Drugs
Diseases
GWAS		Metabolic syndrome ( 20694148)
Protein-Protein Interactions		12 interactors: ACVR1 ACVR2A BMP2 BMP7 INHBA TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3	6 interactors: ACVR2A ENG PPP1CA PPP1CC TGFBR2 TGFBR3
Entrez ID		2022	343521
HPRD ID		00565	15762
Ensembl ID		ENSG00000106991	ENSG00000188396
Uniprot IDs		B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0	Q5JR98
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Protein Phosphorylation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Mesenchymal Cell Development Positive Regulation Of Phosphorylation Mesenchymal Cell Differentiation Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Organ Morphogenesis Response To Growth Factor Regulation Of Bone Mineralization Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Proliferation Embryo Development Regulation Of Ossification Cellular Response To Organic Substance Mesenchyme Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Response To Lipid Growth Positive Regulation Of Cell Differentiation Gland Development Response To Organic Cyclic Compound Regulation Of Phosphorus Metabolic Process Anatomical Structure Morphogenesis Skeletal System Development Stem Cell Differentiation Sensory Organ Development Response To Organic Substance Tissue Development Tissue Morphogenesis Regulation Of Signal Transduction	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance BMP Signaling Pathway Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Response To Organic Substance Negative Regulation Of Signaling Regulation Of Signal Transduction Phosphate-containing Compound Metabolic Process Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Tissue Morphogenesis Triglyceride Catabolic Process Tissue Development Branching Morphogenesis Of An Epithelial Tube Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Nitric-oxide Synthase Activity Cellular Protein Metabolic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Patterning Of Blood Vessels Anatomical Structure Morphogenesis Embryo Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Epithelial Tube Morphogenesis Regulation Of Gene Expression Glycogen Metabolic Process Positive Regulation Of Signal Transduction Tube Morphogenesis Signal Transduction Protein Phosphorylation Organ Regeneration Regulation Of Oxidoreductase Activity
Tagcloud ?		actualization beach biogenic cable cardio collapse craniocorpography ekg electrolytes ending fainting flunarizin holter hypokinesia orthostatic overstrain psychic psycho saved saving sibellium sickness spo ssep telemetric thirst wreck wreckers zpo
Tagcloud (Difference) ?		actualization beach biogenic cable cardio collapse craniocorpography ekg electrolytes ending fainting flunarizin holter hypokinesia orthostatic overstrain psychic psycho saved saving sibellium sickness spo ssep telemetric thirst wreck wreckers zpo
Tagcloud (Intersection) ?