ENG and TGFBR1

Number of citations of the paper that reports this interaction (PMID 12015308)
30

Data Source:
HPRD (in vivo)

		ENG	TGFBR1
Gene Name		endoglin	transforming growth factor, beta receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Focal Adhesion External Side Of Plasma Membrane Cell Surface Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex Endothelial Microparticle	Cell Endosome Plasma Membrane Tight Junction Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Receptor Signaling Protein Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding Growth Factor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding I-SMAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chronological Cell Aging Patterning Of Blood Vessels Vasculogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Systemic Arterial Blood Pressure Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Extracellular Matrix Disassembly Regulation Of Cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Autophosphorylation Response To Corticosteroid Positive Regulation Of Collagen Biosynthetic Process Intracellular Signal Transduction Response To Statin Wound Healing Regulation Of Cell Proliferation Regulation Of Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Cell Motility Negative Regulation Of Nitric-oxide Synthase Activity Cell Chemotaxis Bone Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Extracellular Matrix Constituent Secretion Detection Of Hypoxia Cellular Response To Mechanical Stimulus Response To Transforming Growth Factor Beta	Activation Of MAPKK Activity Skeletal System Development Angiogenesis In Utero Embryonic Development Kidney Development Blastocyst Development Epithelial To Mesenchymal Transition Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lens Development In Camera-type Eye Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Arrest Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Positive Regulation Of Cell Proliferation Germ Cell Migration Male Gonad Development Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Intracellular Signal Transduction Wound Healing Endothelial Cell Activation Extracellular Structure Organization Regulation Of Protein Binding Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Thymus Development Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Mesenchymal Cell Differentiation Artery Morphogenesis Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Palate Development Pharyngeal System Development Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus Response To Cholesterol Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Loss of Function of TGFBR2 in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Metabolic syndrome ( 20694148)	Age-related macular degeneration ( 23455636) Dental caries ( 23064961)
Protein-Protein Interactions		12 interactors: ACVR1 ACVR2A BMP2 BMP7 INHBA TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3	159 interactors: ACVR1 ACVRL1 AMHR2 ANAPC5 AP2B1 ARHGAP15 ARHGAP31 ARHGEF6 ARL4D ARL8B ASH2L AURKB BAMBI BMPR1B BMPR2 BTBD2 CAV1 CD44 CDC20 CDC42EP4 CDK14 CDK17 CDK4 CDK6 CDKL1 CHN1 CHN2 CHUK CLU CSNK1A1 CSNK2A2 CTNNB1 CUL5 DAB2 DAPK2 DCAF12 DCAF6 DUSP13 EIF2AK4 ENC1 ENG FANCL FBXL12 FBXO34 FKBP1A FNTA GNA13 GNB2 GNB3 IKBKB ITK KATNB1 KCNK18 KLHL1 KLHL35 LIMS1 MAP3K7 MYO3A MYOC NAT8 NEK6 NEK8 NKIRAS1 NRP1 NUAK2 NUP37 OSR1 OXSR1 PAK1 PARD6A PIK3R1 PIK3R2 PLEK PLEKHB1 PLEKHJ1 PLK4 PML POMK PPP2R2A PPP3CC PPP6C PREB PREX2 PRPF4 RAB13 RAB25 RAB33B RAB34 RAB38 RAB3B RAB6B RAN RAP2A RASD2 RASL12 RGS19 RHEBL1 RHOA RHOD RHOG RHOH RHOJ RHPN2 RNF130 RNF146 RNF5 RPAP3 RPS27A RRH RTKN SAMD8 SAT2 SKAP2 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SMURF2 SNTG1 SNX6 SOCS6 SQSTM1 STK35 STRAP STUB1 STX8 STYXL1 TGFB1 TGFB2 TGFB3 TGFBR2 TGFBRAP1 TNNT1 TRAF6 TRAP1 TSC22D1 TSSK1B TSSK4 TTC1 TTC27 TTPAL UBA52 UBB UBD UBE2E3 UBE2Z UBXN1 USP4 USP45 VEPH1 WDR13 WDR33 WDR61 XIAP ZAK ZFYVE9
Entrez ID		2022	7046
HPRD ID		00565	01822
Ensembl ID		ENSG00000106991	ENSG00000106799
Uniprot IDs		B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0	P36897 Q5T7S2
PDB IDs			1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Ossification Positive Regulation Of Protein Phosphorylation Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Mesenchymal Cell Development Positive Regulation Of Phosphorylation Mesenchymal Cell Differentiation Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Organ Morphogenesis Response To Growth Factor Regulation Of Bone Mineralization Regulation Of Protein Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Proliferation Embryo Development Regulation Of Ossification Cellular Response To Organic Substance Mesenchyme Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Response To Lipid Growth Positive Regulation Of Cell Differentiation Gland Development Response To Organic Cyclic Compound Regulation Of Phosphorus Metabolic Process Anatomical Structure Morphogenesis Skeletal System Development Stem Cell Differentiation Sensory Organ Development Response To Organic Substance Tissue Development Tissue Morphogenesis Regulation Of Signal Transduction	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Intracellular Signal Transduction Response To Transforming Growth Factor Beta Signal Transduction Cell Communication Signaling Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Growth Factor Cellular Response To Stimulus Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Modification Process Regulation Of Signaling Response To Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Process Positive Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Organic Substance Protein Phosphorylation Phosphorylation Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Organization Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Process Signal Transduction By Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Morphogenesis SMAD Protein Complex Assembly Regulation Of Cell Death Negative Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial To Mesenchymal Transition
Tagcloud ?		actualization beach biogenic cable cardio collapse craniocorpography ekg electrolytes ending fainting flunarizin holter hypokinesia orthostatic overstrain psychic psycho saved saving sibellium sickness spo ssep telemetric thirst wreck wreckers zpo	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		actualization beach biogenic cable cardio collapse craniocorpography ekg electrolytes ending fainting flunarizin holter hypokinesia orthostatic overstrain psychic psycho saved saving sibellium sickness spo ssep telemetric thirst wreck wreckers zpo	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?