ARHGAP8

Description		Rho GTPase activating protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endocytic Recycling
Pathways		RHOA GTPase cycle
Drugs
Diseases
GWAS		Binge eating behaviour in bipolar disorder ( 29391396) Body mass index ( 28552196) Electroencephalographic traits in alcoholism ( 22554406) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Weight ( 28552196)
Interacting Genes		7 interacting genes: BNIP2 CFTR CTTN CYGB RHOA SH3GL1 ZMYND12
Entrez ID		23779
HPRD ID		06448
Ensembl ID		ENSG00000241484
Uniprot IDs		P85298 Q6PJW1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Smooth Muscle Contraction Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Neuron Differentiation Odontogenesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Muscle Contraction Skeletal Muscle Satellite Cell Migration Cell Projection Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Podosome Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Beta Selection Glutamatergic Synapse Positive Regulation Of Monoatomic Anion Transport Catalase Activity Carbon Monoxide Binding Bone Trabecula Morphogenesis Dendritic Spine Positive Regulation Of Enamel Mineralization Superoxide Dismutase Activity Nitrite Reductase Activity Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Cytoskeleton Organization Lamellipodium Endosome Cleavage Furrow Formation Regulation Of Neuron Differentiation Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Regulation Of Systemic Arterial Blood Pressure By Endothelin Cell Junction Regulation Of Muscle Contraction Positive Regulation Of Protein-containing Complex Assembly Roundabout Signaling Pathway Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Early Endosome Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport
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