ARHGAP8 and SH3GL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo, in vitro)

		ARHGAP8	SH3GL1
Description		Rho GTPase activating protein 8	SH3 domain containing GRB2 like 1, endophilin A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Podosome Cytoplasm Endosome Cytosol Membrane Early Endosome Membrane Cell Projection Anchoring Junction Presynapse Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding	Protein Binding Lipid Binding Identical Protein Binding Cadherin Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Endocytic Recycling	Endocytosis Signal Transduction Central Nervous System Development
Pathways		RHOA GTPase cycle	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Binge eating behaviour in bipolar disorder ( 29391396) Body mass index ( 28552196) Electroencephalographic traits in alcoholism ( 22554406) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Weight ( 28552196)	Appendicular lean mass ( 33097823) Hematocrit ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		7 interacting genes: BNIP2 CFTR CTTN CYGB RHOA SH3GL1 ZMYND12	35 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 EEIG1 FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 SYNJ1 VPS37C YWHAZ
Entrez ID		23779	6455
HPRD ID		06448	03462
Ensembl ID		ENSG00000241484	ENSG00000141985
Uniprot IDs		P85298 Q6PJW1	Q6FGM0 Q99961
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Smooth Muscle Contraction Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Neuron Differentiation Odontogenesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Muscle Contraction Skeletal Muscle Satellite Cell Migration Cell Projection Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Podosome Negative Regulation Of Hepatic Stellate Cell Activation Nitric Oxide Catabolic Process Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor Beta Selection Glutamatergic Synapse Positive Regulation Of Monoatomic Anion Transport Catalase Activity Carbon Monoxide Binding Bone Trabecula Morphogenesis Dendritic Spine Positive Regulation Of Enamel Mineralization Superoxide Dismutase Activity Nitrite Reductase Activity Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Cytoskeleton Organization Lamellipodium Endosome Cleavage Furrow Formation Regulation Of Neuron Differentiation Positive Regulation Of Supramolecular Fiber Organization Cell Cortex Regulation Of Systemic Arterial Blood Pressure By Endothelin Cell Junction Regulation Of Muscle Contraction Positive Regulation Of Protein-containing Complex Assembly Roundabout Signaling Pathway Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Early Endosome Membrane Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport	Negative Regulation Of Endocytic Recycling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytoplasm Membrane Fission
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