ELN and FBLN1

Number of citations of the paper that reports this interaction (PMID 10544250)
12

Data Source:
HPRD (in vitro)

		ELN	FBLN1
Gene Name		elastin	fibulin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Elastic Fiber	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Peptidase Activator Activity
	Biological Process	Respiratory Gaseous Exchange Blood Circulation Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization	Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization
Pathways		Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix	Molecules associated with elastic fibres Elastic fibre formation
Drugs		Rofecoxib
Diseases
GWAS			Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		21 interactors: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 NID2 PRTN3 SPINK1	35 interactors: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CTGF ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MFAP5 MOB4 NEDD1 NID1 NOTCH3 NOV PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 VCAN YWHAQ
Entrez ID		2006	2192
HPRD ID		00556	00629
Ensembl ID		ENSG00000049540	ENSG00000077942
Uniprot IDs		B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4	P23142 Q8NBH6
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Response To Other Organism Response To Biotic Stimulus Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Response To Bacterium Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Extracellular Negative Regulation Of Signal Transduction Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Chondroitin Sulfate Biosynthetic Process Regulation Of Calcium Ion Import Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Interleukin-8 Production Response To External Stimulus Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Lipid Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Peptide Cross-linking Defense Response Negative Regulation Of Endocytosis Multicellular Organismal Development Argininosuccinate Metabolic Process Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Microglial Cell Proliferation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process System Development Response To Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Collagen Catabolic Process Wound Healing Immune System Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein Deamination Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cellular Response To Amine Stimulus Neutrophil Mediated Killing Of Fungus	Extracellular Matrix Organization Extracellular Structure Organization Organ Development Regulation Of Cellular Component Organization System Development Multicellular Organismal Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Morphogenesis Anatomical Structure Development Positive Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Regulation Of Cell Development Cardiovascular System Development Regulation Of Cell Growth Regulation Of Signaling Tissue Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Anatomical Structure Formation Involved In Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Regulation Of Cell Morphogenesis Angiogenesis Positive Regulation Of Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding Blood Vessel Development Vasculature Development Negative Regulation Of Cell Death Central Nervous System Development Regulation Of Protein Metabolic Process DNA-templated Transcription, Initiation Locomotion Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Wound Healing Negative Regulation Of Signal Transduction Blood Vessel Morphogenesis Positive Regulation Of Cell Differentiation Ossification Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Difference) ?		additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Intersection) ?