ELN and FBLN2

Number of citations of the paper that reports this interaction (PubMedID 10544250)
0

Data Source:
HPRD (in vitro)

		ELN	FBLN2
Description		elastin	fibulin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Elastic Fiber	Extracellular Region Extracellular Matrix Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding
	Biological Process	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange By Respiratory System Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly	Positive Regulation Of Cell-substrate Adhesion
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Rofecoxib
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Congenital supravalvar aortic stenosis
GWAS		Diverticular disease ( 30177863) Height ( 31562340)	Appendicular lean mass ( 33097823) Bipolar disorder with mood-incongruent psychosis ( 23092984) Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		25 interacting genes: ARLN ASS1 ATP2A2 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PLN PRTN3 SPINK1	32 interacting genes: ACAN ATN1 BCAN COL18A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL8A1 ELN ERCC6 FBN1 FBXW5 FN1 HOXA1 HSD3B7 HSPG2 ITGB3 JOSD1 LAMA1 LAMA5 LAMC2 LCE3D NID1 NUFIP2 OTX1 PRELP VCAN ZNF408 ZNF414
Entrez ID		2006	2199
HPRD ID		00556	00630
Ensembl ID		ENSG00000049540	ENSG00000163520
Uniprot IDs		B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4	P98095 Q86V58
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Microfibril Extracellular Matrix Organization Extracellular Structure Organization Calcium Ion-transporting ATPase Complex Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Basement Membrane Extracellular Matrix Binding Regulation Of Multicellular Organismal Process Calcium Ion Binding Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Regulation Of Cardiac Muscle Cell Membrane Potential Humoral Immune Response Killing Of Cells Of Another Organism Fibrinogen Binding Post-embryonic Eye Morphogenesis Regulation Of Calcium Ion Import Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Collagen Fibril Organization Extracellular Negative Regulation Of Signal Transduction Relaxation Of Cardiac Muscle Extracellular Matrix Structural Constituent Conferring Compression Resistance Sensory Organ Morphogenesis Cell Killing Negative Regulation Of Calcium Ion Import Azurophil Granule Lumen Relaxation Of Muscle Negative Regulation Of Heart Contraction Response To External Biotic Stimulus Extracellular Exosome Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Circulation Glycosaminoglycan Binding Muscle Cell Cellular Homeostasis Regulation Of The Force Of Heart Contraction Defense Response To Symbiont Negative Regulation Of Signal Transduction Defense Response To Other Organism Extracellular Matrix Assembly Embryonic Organ Morphogenesis Fibronectin Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Endocytosis	Basement Membrane Extracellular Matrix Structural Constituent Extracellular Matrix Collagen Type IV Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Endoplasmic Reticulum Lumen Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Region Collagen-activated Signaling Pathway Cell Adhesion Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Extracellular Structure Organization Extracellular Matrix Organization Integrin Binding Lysosomal Lumen Perineuronal Net Glomerular Basement Membrane Development Skeletal System Development Golgi Lumen Angiogenesis System Development Hyaluronic Acid Binding Extracellular Matrix Binding Endodermal Cell Differentiation Retinal Blood Vessel Morphogenesis Extracellular Space Substrate Adhesion-dependent Cell Spreading Regulation Of Basement Membrane Organization Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Formation Involved In Morphogenesis Blood Coagulation, Fibrin Clot Formation Protein Complex Involved In Cell-matrix Adhesion Retina Vasculature Morphogenesis In Camera-type Eye Extracellular Matrix Constituent Conferring Elasticity Central Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Insulin-like Growth Factor Stimulus Cell-substrate Adhesion Heparin Binding Branching Involved In Salivary Gland Morphogenesis Proteoglycan Binding Positive Regulation Of Integrin-mediated Signaling Pathway Regulation Of Extracellular Matrix Organization Response To Activity Protein Activation Cascade Regulation Of Cell Adhesion Regulation Of Cell-substrate Adhesion Regulation Of Integrin-mediated Signaling Pathway
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