ELN and BGN

Number of citations: 0 (PubMedID 11723132)
Data Source: BioGRID (pull down), HPRD (in vivo)

		ELN	BGN
Name		elastin	biglycan
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Elastic Fiber	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Cytokine Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding
	Biological Process	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange By Respiratory System Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly	Blood Vessel Remodeling Bone Development Articular Cartilage Development
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs		Rofecoxib	None
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Congenital supravalvar aortic stenosis	None
GWAS		Diverticular disease ( 30177863 ) Height ( 31562340 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: ALMS1	None recorded
Interacting Genes		25 interacting genes: ARLN ASS1 ATP2A2 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PLN PRTN3 SPINK1	21 interacting genes: - APOB APP BMP4 CCN4 COL18A1 COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL6A1 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 THBS1 TNF
Entrez ID		2006	633
HPRD ID		00556	02359
Ensembl ID		ENSG00000049540	ENSG00000182492
Uniprot IDs		B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4	B4DNL4 P21810
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Microfibril Extracellular Matrix Organization Extracellular Structure Organization Calcium Ion-transporting ATPase Complex Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Basement Membrane Extracellular Matrix Binding Regulation Of Multicellular Organismal Process Calcium Ion Binding Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Regulation Of Cardiac Muscle Cell Membrane Potential Humoral Immune Response Killing Of Cells Of Another Organism Fibrinogen Binding Post-embryonic Eye Morphogenesis Regulation Of Calcium Ion Import Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Collagen Fibril Organization Extracellular Negative Regulation Of Signal Transduction Relaxation Of Cardiac Muscle Extracellular Matrix Structural Constituent Conferring Compression Resistance Sensory Organ Morphogenesis Cell Killing Negative Regulation Of Calcium Ion Import Azurophil Granule Lumen Relaxation Of Muscle Negative Regulation Of Heart Contraction Response To External Biotic Stimulus Extracellular Exosome Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Circulation Glycosaminoglycan Binding Muscle Cell Cellular Homeostasis Regulation Of The Force Of Heart Contraction Defense Response To Symbiont Negative Regulation Of Signal Transduction Defense Response To Other Organism Extracellular Matrix Assembly Embryonic Organ Morphogenesis Fibronectin Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Endocytosis	Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Platelet-derived Growth Factor Binding Anatomical Structure Morphogenesis Collagen Trimer Animal Organ Morphogenesis Basement Membrane Extracellular Space Response To Mechanical Stimulus Anatomical Structure Formation Involved In Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Cellular Response To Growth Factor Stimulus Negative Regulation Of MiRNA Transcription Extracellular Matrix Assembly Cellular Response To Amino Acid Stimulus Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Response To Growth Factor Fibrillar Collagen Trimer Developmental Process Response To Amino Acid Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Fibril Organization Response To Xenobiotic Stimulus Heparin Binding Tube Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Primary MiRNA Processing Collagen Type I Trimer System Development Bone Development Regulation Of MiRNA Transcription Animal Organ Development Response To Activity Skeletal System Development Positive Regulation Of Cell Migration System Process Positive Regulation Of Cell Motility Regulation Of MiRNA Metabolic Process Positive Regulation Of Locomotion Positive Regulation Of Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Mononuclear Cell Migration Cell Surface Receptor Signaling Pathway