ELN and FCN1

Number of citations of the paper that reports this interaction (PubMedID 8947836)
0

Data Source:
HPRD (in vitro)

		ELN	FCN1
Description		elastin	ficolin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Elastic Fiber	Extracellular Region Collagen Trimer Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Matrix Secretory Granule Lumen Symbiont Cell Surface Ficolin-1-rich Granule Lumen Serine-type Endopeptidase Complex
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Binding	G Protein-coupled Receptor Binding Antigen Binding Signaling Receptor Binding Protein Binding Carbohydrate Binding Sialic Acid Binding Pattern Recognition Receptor Activity Metal Ion Binding Carbohydrate Derivative Binding
	Biological Process	Outflow Tract Morphogenesis Aortic Valve Morphogenesis Skeletal Muscle Tissue Development Respiratory Gaseous Exchange By Respiratory System Blood Circulation Animal Organ Morphogenesis Extracellular Matrix Organization Regulation Of Actin Filament Polymerization Stress Fiber Assembly Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly	Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Proteolysis Complement Activation G Protein-coupled Receptor Signaling Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Positive Regulation Of Interleukin-8 Production Protein Localization To Cell Surface Recognition Of Apoptotic Cell Innate Immune Response Host-mediated Suppression Of Symbiont Invasion Protein Maturation Positive Regulation Of Opsonization
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Neutrophil degranulation
Drugs		Rofecoxib
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome Congenital supravalvar aortic stenosis
GWAS		Diverticular disease ( 30177863) Height ( 31562340)	Blood protein levels ( 30072576) Trans-epidermal water loss ( 28011148)
Interacting Genes		25 interacting genes: ARLN ASS1 ATP2A2 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 MTDH NID2 PLN PRTN3 SPINK1	2 interacting genes: ELN TGFB1
Entrez ID		2006	2219
HPRD ID		00556	03153
Ensembl ID		ENSG00000049540	ENSG00000085265
Uniprot IDs		B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4	O00602
PDB IDs			2D39 2JHH 2JHI 2JHK 2JHL 2JHM 2WNP
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Space Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity Microfibril Extracellular Matrix Organization Extracellular Structure Organization Calcium Ion-transporting ATPase Complex Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Basement Membrane Extracellular Matrix Binding Regulation Of Multicellular Organismal Process Calcium Ion Binding Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Regulation Of Cardiac Muscle Cell Membrane Potential Humoral Immune Response Killing Of Cells Of Another Organism Fibrinogen Binding Post-embryonic Eye Morphogenesis Regulation Of Calcium Ion Import Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Collagen Fibril Organization Extracellular Negative Regulation Of Signal Transduction Relaxation Of Cardiac Muscle Extracellular Matrix Structural Constituent Conferring Compression Resistance Sensory Organ Morphogenesis Cell Killing Negative Regulation Of Calcium Ion Import Azurophil Granule Lumen Relaxation Of Muscle Negative Regulation Of Heart Contraction Response To External Biotic Stimulus Extracellular Exosome Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Blood Circulation Glycosaminoglycan Binding Muscle Cell Cellular Homeostasis Regulation Of The Force Of Heart Contraction Defense Response To Symbiont Negative Regulation Of Signal Transduction Defense Response To Other Organism Extracellular Matrix Assembly Embryonic Organ Morphogenesis Fibronectin Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Endocytosis	Regulation Of Actin Cytoskeleton Organization Aortic Valve Morphogenesis Regulation Of Actin Filament-based Process Extracellular Matrix Assembly Regulation Of Cytoskeleton Organization Heart Valve Morphogenesis Myelination Tube Closure Axon Ensheathment Neural Tube Closure Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Tube Formation Cellular Response To Acetaldehyde Memory T Cell Differentiation Regulation Of Smooth Muscle Cell Proliferation T Cell Differentiation Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Regulation Of Organelle Organization Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Extracellular Structure Organization Regulation Of Actin Filament Organization Regulation Of Cell Population Proliferation Regulation Of Cellular Component Size Elastic Fiber Extracellular Matrix Organization System Process Circulatory System Process Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of MiRNA Processing Myofibroblast Differentiation Mononuclear Cell Differentiation Foam Cell Differentiation Bronchiole Development Lymphocyte Differentiation Macrophage Derived Foam Cell Differentiation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Adaptive Immune Response Positive Regulation Of Exit From Mitosis Negative Regulation Of Skeletal Muscle Tissue Development Response To Decreased Oxygen Levels Frontal Suture Morphogenesis Mammary Gland Branching Involved In Thelarche Type III Transforming Growth Factor Beta Receptor Binding Tolerance Induction To Self Antigen T Cell Activation Positive Regulation Of Isotype Switching To IgA Isotypes
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